{"id":"W2039481158","doi":"10.1038/srep01472","title":"Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RIKEN Brain Science Institute; RIKEN; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Vector Institute; Novartis Institutes for BioMedical Research; Ministry of Health, Labour and Welfare","keywords":"Neprilysin; Genetic enhancement; Viral vector; Vector (molecular biology); Gene delivery; Transduction (biophysics); Hippocampus; Neuroscience; Medicine; Adeno-associated virus; Pharmacology; Gene; Biology; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005117193,0.00009797489,0.0002408307,0.0001017255,0.00003453306,0.00003138648,0.00005869147,0.00005475296,0.0002200053],"category_scores_gemma":[0.0001506432,0.00008385204,0.0001034977,0.0004966936,0.0002231913,0.000137831,0.000032815,0.00004511889,0.00002023296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008097311,"about_ca_system_score_gemma":0.0005493937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007720485,"about_ca_topic_score_gemma":0.00005530625,"domain_scores_codex":[0.9981999,0.00005823236,0.0004842828,0.0003916094,0.0006369531,0.0002290561],"domain_scores_gemma":[0.9988214,0.00002390421,0.0001973024,0.0004691509,0.000279226,0.0002089984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00039312,0.00364678,0.3839089,0.0003412942,0.002803846,0.002702286,0.0002328132,0.00001943577,0.5360474,0.00004371196,0.05894279,0.01091759],"study_design_scores_gemma":[0.001674857,0.000520752,0.440262,0.000198385,0.0003181353,0.0004447862,0.00016598,0.0003516998,0.553336,0.001725621,0.0007807034,0.0002210486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996105,0.00250166,0.00002512668,0.0001985179,0.0002592806,0.0005651331,0.00001895837,0.00001078489,0.0003155839],"genre_scores_gemma":[0.9992188,0.00001419794,0.0003447479,0.00001481264,0.00001568695,0.00002263818,0.0002373666,0.000006132749,0.0001256418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05816209,"threshold_uncertainty_score":0.3419387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252448129520302,"score_gpt":0.282391638761664,"score_spread":0.269867157466461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}