{"id":"W2039481158","doi":"10.1038/srep01472","title":"Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RIKEN Brain Science Institute; RIKEN; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Vector Institute; Novartis Institutes for BioMedical Research; Ministry of Health, Labour and Welfare","keywords":"Neprilysin; Genetic enhancement; Viral vector; Vector (molecular biology); Gene delivery; Transduction (biophysics); Hippocampus; Neuroscience; Medicine; Adeno-associated virus; Pharmacology; Gene; Biology; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005081439,0.001150422,0.0007328776,0.001410603,0.0004262906,0.0006217139,0.0008146309,0.001545399,0.001618061],"category_scores_gemma":[0.0001760151,0.0005755128,0.0006707499,0.0004162119,0.0009465845,0.0008440969,0.0004271731,0.002012981,0.0008171471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006210533,"about_ca_system_score_gemma":0.000646993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009790424,"about_ca_topic_score_gemma":0.001123753,"domain_scores_codex":[0.9995753,0.00004354324,0.00005833506,0.0001732003,0.00007137859,0.00007815331],"domain_scores_gemma":[0.9997628,0.00002944875,0.00006831861,0.00004008759,0.0000276228,0.0000717164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002318147,0.000223157,0.00007726807,0.00006615937,0.00001538724,0.00008701131,0.00006474047,0.0001413233,0.9951553,0.0006423606,0.0001670006,0.003128404],"study_design_scores_gemma":[0.0001859392,0.00174167,0.0008170875,0.00003249104,0.00007526498,0.0005918812,0.00002875421,0.002238613,0.9873084,0.0003405072,0.00661963,0.00001969694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9163705,0.005458151,0.0651838,0.0009434014,0.000400634,0.001113155,0.002784237,0.002689264,0.00505697],"genre_scores_gemma":[0.8953791,0.006033762,0.0763705,0.0003418204,0.0001552213,0.001613411,0.0035197,0.0003448311,0.01624176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618061,"threshold_uncertainty_score":0.005412936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252448129520302,"score_gpt":0.282391638761664,"score_spread":0.269867157466461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}