{"id":"W2039501969","doi":"10.1371/journal.pgen.1000852","title":"Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair","year":2010,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Killam Trusts; Israel Science Foundation","keywords":"Biology; Proteasome; DNA repair; DNA damage; Genome instability; Chromatin; Protein subunit; Cell biology; Ubiquitin; Homologous recombination; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113627,0.0004688315,0.0002207661,0.0001452199,0.0001126211,0.0004222653,0.0001539878,0.0001268957,0.0008836502],"category_scores_gemma":[0.0001302851,0.00009638278,0.0001230869,0.0001529077,0.0001805518,0.0001342331,0.0001585536,0.0002344513,0.0002262969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003144901,"about_ca_system_score_gemma":0.0001278595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004982399,"about_ca_topic_score_gemma":0.001239804,"domain_scores_codex":[0.9999261,0.00001119337,0.000007498714,0.00002161691,0.00001947511,0.00001412129],"domain_scores_gemma":[0.999898,0.00001580714,0.00003385348,0.00001597619,0.00001084919,0.00002560716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004884856,0.000007793038,0.0002580163,0.00001138136,0.000003015763,0.00002538281,0.000003379321,0.00003226442,0.9988294,0.00004098362,0.00001281044,0.000726802],"study_design_scores_gemma":[0.00000398404,0.0001336172,0.003306557,0.000001956214,0.000008255233,0.000188145,0.000009559066,0.0004431538,0.9948246,0.00002416169,0.001054023,0.000001862382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933162,0.002791438,0.002585054,0.00005192861,0.00001513005,0.000009955148,0.0003179424,0.00009906152,0.0008132966],"genre_scores_gemma":[0.9965635,0.0008324336,0.001269114,0.00001208845,0.000005320844,0.000006660964,0.0002989802,0.00001701187,0.0009949267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008836502,"threshold_uncertainty_score":0.002956092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307349094444383,"score_gpt":0.227534652450167,"score_spread":0.2144611615057232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}