{"id":"W2039531123","doi":"10.1021/bp0702121","title":"Physiological Improvement to Enhance <i>Escherichia coli</i> Cell‐Surface Display via Reducing Extracytoplasmic Stress","year":2008,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Periplasmic space; Escherichia coli; Bacterial outer membrane; Biology; Cell; Cell biology; Cell membrane; Cell physiology; Chaperone (clinical); Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212879,0.0008737235,0.0004220444,0.0001492629,0.0001321577,0.0004681667,0.0003191321,0.0002956224,0.000708206],"category_scores_gemma":[0.0002378309,0.0001943664,0.0003366752,0.0001725803,0.0002246669,0.0003270061,0.0004556776,0.0008081078,0.0004421131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002722146,"about_ca_system_score_gemma":0.0002372868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004777682,"about_ca_topic_score_gemma":0.0004565093,"domain_scores_codex":[0.9998156,0.00004547839,0.00002230805,0.00003129003,0.00004195943,0.00004333276],"domain_scores_gemma":[0.999851,0.00002575353,0.00003886988,0.00002494657,0.00003019514,0.00002926474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007750517,0.000009170184,0.0000394233,0.0000107316,0.00000113113,0.0000114763,0.000004977504,0.00001752053,0.9995147,0.0000259295,0.00001106651,0.0003461853],"study_design_scores_gemma":[0.000002247834,0.00005425909,0.001107649,0.000001844442,0.000007205667,0.0001076109,0.00001107231,0.0004683012,0.9974553,0.00001316048,0.0007683451,0.000002922979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723718,0.0005768217,0.02414848,0.0002671365,0.00003935404,0.00007659561,0.0002680097,0.0003954046,0.001856284],"genre_scores_gemma":[0.9800732,0.0006646796,0.01636229,0.000131318,0.00001234295,0.00004931154,0.000621583,0.0001348167,0.001950465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008737235,"threshold_uncertainty_score":0.002369165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007532924033209589,"score_gpt":0.2405729855673263,"score_spread":0.2330400615341167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}