{"id":"W2039533616","doi":"10.3389/fgene.2014.00419","title":"Phospholipase A2 â€“ nexus of aging, oxidative stress, neuronal excitability, and functional decline of the aging nervous system? Insights from a snail model system of neuronal aging and age-associated memory impairment","year":2014,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Medicinal Plants and Neuroprotection","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroscience; Context (archaeology); Lymnaea stagnalis; Brain aging; Aging brain; Neurodegeneration; Oxidative stress; Cognitive decline; Biology; Disease; Memory impairment; Ageing; Psychology; Cognition; Snail; Medicine; Dementia; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004766547,0.0004731762,0.002232565,0.0002970461,0.0000810117,0.00001419462,0.0002027951,0.0002554787,0.000002598832],"category_scores_gemma":[0.0001363143,0.0003411656,0.0002424287,0.0002860045,0.0003584473,0.00003821048,0.0002975322,0.0006413459,1.41649e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128652,"about_ca_system_score_gemma":0.0003267541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002909327,"about_ca_topic_score_gemma":0.00004762887,"domain_scores_codex":[0.9963433,0.0005781878,0.001399973,0.0006137671,0.0007917851,0.0002730089],"domain_scores_gemma":[0.9975687,0.0002327752,0.00136997,0.0005001633,0.0001707786,0.000157585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001508346,0.00274582,0.04701917,0.5299094,0.005018806,0.0005534276,0.007442724,0.01534323,0.002762893,0.0002389117,0.002195288,0.385262],"study_design_scores_gemma":[0.01929585,0.004296754,0.1749712,0.3390866,0.02020069,0.0007735461,0.005939332,0.4186625,0.003972705,0.0006740481,0.009120218,0.00300661],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3473721,0.6476055,0.001854399,0.00002350261,0.001162414,0.00152227,0.0003726929,0.00002441285,0.00006269865],"genre_scores_gemma":[0.6767362,0.3218363,0.0008103381,0.00005183212,0.0002086398,0.00004780103,0.0001739427,0.00008208983,0.00005283495],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4033193,"threshold_uncertainty_score":0.999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495949292859223,"score_gpt":0.2564217690344452,"score_spread":0.231462276105853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}