{"id":"W2039625583","doi":"10.1139/y10-024","title":"Arecoline excites the contraction of distal colonic smooth muscle strips in rats via the M<sub>3</sub>receptor – extracellular Ca<sup>2+</sup>influx – Ca<sup>2+</sup>store release pathway","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tongji University; National Natural Science Foundation of China","keywords":"Arecoline; EGTA; Endocrinology; Chemistry; Internal medicine; Contraction (grammar); Muscarinic acetylcholine receptor; Muscle contraction; Methoctramine; Extracellular; Acetylcholine; Tetrodotoxin; Receptor; Biochemistry; Muscarinic acetylcholine receptor M3; Calcium; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169721,0.0007731259,0.0005772692,0.0003993726,0.0001998388,0.000153057,0.0002074999,0.0005148125,0.002158777],"category_scores_gemma":[0.0001736645,0.0002888718,0.0005969597,0.0002554642,0.0003318451,0.0003834745,0.0002202919,0.001191143,0.0002524899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479375,"about_ca_system_score_gemma":0.0002924794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008247922,"about_ca_topic_score_gemma":0.00220363,"domain_scores_codex":[0.9998972,0.0000135722,0.0000105981,0.00001643305,0.000020633,0.0000414546],"domain_scores_gemma":[0.999798,0.00002343816,0.00006770192,0.00002260419,0.0000193145,0.00006901858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001397979,0.0001559192,0.0004175335,0.00008954993,0.00001637916,0.0001465122,0.00002232987,0.00003415982,0.9958609,0.00003925028,0.00004948936,0.001770011],"study_design_scores_gemma":[0.0003413947,0.01448537,0.05607035,0.00002825045,0.00015836,0.0005654652,0.0001969189,0.001017763,0.924925,0.00009913158,0.002088846,0.00002321761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969991,0.001162197,0.0006571815,0.0001776394,0.00004526231,0.00003366972,0.0001361949,0.00004773113,0.000740988],"genre_scores_gemma":[0.9928138,0.002321842,0.001669082,0.0002269815,0.00005631313,0.0001109488,0.0003448269,0.0000137941,0.00244241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002158777,"threshold_uncertainty_score":0.007221878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221649166859002,"score_gpt":0.2349424539656016,"score_spread":0.2227259622970116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}