{"id":"W2039625583","doi":"10.1139/y10-024","title":"Arecoline excites the contraction of distal colonic smooth muscle strips in rats via the M<sub>3</sub>receptor – extracellular Ca<sup>2+</sup>influx – Ca<sup>2+</sup>store release pathway","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tongji University; National Natural Science Foundation of China","keywords":"Arecoline; EGTA; Endocrinology; Chemistry; Internal medicine; Contraction (grammar); Muscarinic acetylcholine receptor; Muscle contraction; Methoctramine; Extracellular; Acetylcholine; Tetrodotoxin; Receptor; Biochemistry; Muscarinic acetylcholine receptor M3; Calcium; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007932796,0.0003099957,0.0005292203,0.0002654371,0.0006235373,0.00002814257,0.00053556,0.0003563636,0.001517502],"category_scores_gemma":[0.0003258169,0.0002045035,0.0001886791,0.0003364757,0.001256708,0.0002337145,0.00004266037,0.001882233,0.00002834995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020533,"about_ca_system_score_gemma":0.0009456443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009565231,"about_ca_topic_score_gemma":0.002614446,"domain_scores_codex":[0.997039,0.00103429,0.0007035914,0.0003746565,0.0001637436,0.0006847096],"domain_scores_gemma":[0.9974927,0.001078585,0.0005536734,0.0001792152,0.0001870092,0.0005088052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002459047,0.0000966651,0.00009010427,0.00003314902,0.00003580739,0.0001015938,0.002478993,0.01007247,0.9811155,0.00008546348,0.004182027,0.001462282],"study_design_scores_gemma":[0.001809196,0.0005507333,0.001029165,0.00002689029,0.00008585062,0.0002266979,0.001056101,0.02040445,0.9373873,0.0004432425,0.03666997,0.0003103383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938411,0.0006206805,0.00001279619,0.00264433,0.002208808,0.0004429613,0.0001965575,0.000007435793,0.00002539938],"genre_scores_gemma":[0.9973441,0.0003400554,0.000006042404,0.001203502,0.000973115,0.00002675338,0.00001535835,0.00002883988,0.00006227245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04372818,"threshold_uncertainty_score":0.9993953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221649166859002,"score_gpt":0.2349424539656016,"score_spread":0.2227259622970116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}