{"id":"W2039625693","doi":"10.1016/j.ejpb.2006.08.017","title":"In vitro evaluation of the mucoadhesive properties of polysaccharide-based nanoparticulate oral drug delivery systems","year":2006,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Quartz crystal microbalance; Chemistry; Chitosan; Bioavailability; Adsorption; Drug delivery; Mucoadhesion; Polysaccharide; Dextran; Amphiphile; Chromatography; Polymer; Surface plasmon resonance; Micelle; Xanthan gum; Chemical engineering; Drug carrier; Nanoparticle; Organic chemistry; Aqueous solution; Materials science; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005100539,0.000386008,0.0003537899,0.0001864754,0.0001651541,0.0002148937,0.0001771857,0.0003040548,0.0007136644],"category_scores_gemma":[0.0005532944,0.0001748475,0.0004318846,0.0002304931,0.0001850317,0.0002857617,0.000160927,0.0004124252,0.0001412533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000183177,"about_ca_system_score_gemma":0.0002137826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009668653,"about_ca_topic_score_gemma":0.001055112,"domain_scores_codex":[0.9997092,0.00008956377,0.00002790611,0.00002873966,0.00009399802,0.00005053742],"domain_scores_gemma":[0.9996743,0.000136646,0.00006125173,0.0000187869,0.00007907183,0.00002982061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002185961,0.00007394564,0.0001184514,0.00008752502,0.00001550267,0.00003905896,0.00003104492,0.0001688639,0.9977187,0.00002705987,0.00001153472,0.001489716],"study_design_scores_gemma":[0.00001151178,0.001397674,0.001444647,0.000005376675,0.00004158144,0.00005263601,0.00001624627,0.0004751771,0.9961354,0.000006287542,0.0004092941,0.000004293164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946685,0.003086514,0.001450363,0.0000334538,0.00002428972,0.00003288337,0.000120594,0.00001101558,0.0005721869],"genre_scores_gemma":[0.9945223,0.002046986,0.002091738,0.00002468983,0.00001427159,0.00002711389,0.000178894,0.000006848355,0.00108721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009668653,"threshold_uncertainty_score":0.002697468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.118779915851783,"score_gpt":0.3738280205773513,"score_spread":0.2550481047255684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}