{"id":"W2039637995","doi":"10.1371/journal.pone.0016679","title":"Specific Age-Associated DNA Methylation Changes in Human Dermal Fibroblasts","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RWTH Aachen University; Bundesministerium für Bildung und Forschung; Stem Cell Network; Deutsches Krebsforschungszentrum","keywords":"DNA methylation; CpG site; Epigenetics; Biology; Methylation; Mesenchymal stem cell; Differentially methylated regions; Cell biology; Molecular biology; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442005,0.0001222289,0.0001314616,0.0002233201,0.0001399958,0.0001571838,0.00006639031,0.00014663,0.001736739],"category_scores_gemma":[0.0001640185,0.0001083302,0.0001542455,0.0001662026,0.00009408218,0.00008221695,0.0001600445,0.0001691443,0.000373264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008510351,"about_ca_system_score_gemma":0.0001067017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195428,"about_ca_topic_score_gemma":0.001641034,"domain_scores_codex":[0.9998976,0.00001185637,0.000008872512,0.00004353315,0.00002209581,0.00001614756],"domain_scores_gemma":[0.9999357,0.00001221653,0.00001420537,0.00001112022,0.00001601187,0.00001078779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001429677,0.000009653082,0.003552133,0.00003017729,0.000009750704,0.0001103637,0.00007279573,0.00002844126,0.9926967,0.00002241754,0.00003902484,0.003285532],"study_design_scores_gemma":[0.00001625203,0.0004824218,0.2088695,0.00001376001,0.00005827969,0.001896107,0.0002425527,0.0003237865,0.7826664,0.0001365705,0.005276052,0.00001828557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886234,0.003911116,0.003697929,0.00004879853,0.00002281901,0.00004370727,0.001368289,0.00003434486,0.002249512],"genre_scores_gemma":[0.9917296,0.001702758,0.001679888,0.00006217783,0.000008025645,0.00005664548,0.001231268,0.000009248603,0.003520495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001736739,"threshold_uncertainty_score":0.005809963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07580946924209195,"score_gpt":0.2453174147767168,"score_spread":0.1695079455346248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}