{"id":"W2039637995","doi":"10.1371/journal.pone.0016679","title":"Specific Age-Associated DNA Methylation Changes in Human Dermal Fibroblasts","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RWTH Aachen University; Bundesministerium für Bildung und Forschung; Stem Cell Network; Deutsches Krebsforschungszentrum","keywords":"DNA methylation; CpG site; Epigenetics; Biology; Methylation; Mesenchymal stem cell; Differentially methylated regions; Cell biology; Molecular biology; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187091,0.0001108207,0.0001363405,0.00007561798,0.00004971629,0.00001299608,0.00009797938,0.0001593741,0.00007836778],"category_scores_gemma":[0.00004845716,0.0001225412,0.00003209811,0.0001045629,0.00003107968,0.000003388154,0.00005114744,0.000073544,0.00001162146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001919854,"about_ca_system_score_gemma":0.00001065821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002785546,"about_ca_topic_score_gemma":0.0004793142,"domain_scores_codex":[0.9991617,0.00008049593,0.0001709686,0.0002469125,0.0001401459,0.0001997927],"domain_scores_gemma":[0.999598,0.000007779665,0.00008409181,0.0002012852,0.00006012103,0.00004874784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001846184,0.0004512455,0.009377127,0.00001161208,0.00004541135,0.000003515215,0.0001819321,0.000003246559,0.9892305,0.00003739658,0.00001889907,0.0006207249],"study_design_scores_gemma":[0.0003366335,0.00023916,0.0923784,0.0000321168,0.00001560672,8.696446e-8,0.0000129773,0.00002148512,0.9062521,0.0004279295,0.0001463506,0.0001371638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995285,0.0005400972,0.000101265,0.00003516932,0.00002551247,0.0001679012,0.000006839796,0.00001472331,0.003823547],"genre_scores_gemma":[0.9978226,0.0002722777,0.001097621,0.00002916419,0.0001132174,0.00001969244,0.0002253034,0.00002184989,0.0003982168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08300127,"threshold_uncertainty_score":0.4997086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07580946924209195,"score_gpt":0.2453174147767168,"score_spread":0.1695079455346248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}