{"id":"W2039639216","doi":"10.3851/imp2821","title":"Naturally Occurring Dominant Drug Resistance Mutations Occur Infrequently in the Setting of Recently Acquired Hepatitis C","year":2014,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Institute on Drug Abuse; National Medical Research Council; National Health and Medical Research Council; National Institutes of Health; Bristol-Myers Squibb; National Health Research Institutes; Australian Government; Gilead Sciences","keywords":"Viral quasispecies; NS5A; Sofosbuvir; Virology; Drug resistance; NS5B; Genotype; Hepatitis C virus; Pyrosequencing; Biology; Hepatitis C; Resistance mutation; Genetics; Hepacivirus; Medicine; Gene; Ribavirin; Polymerase chain reaction; Virus; Reverse transcriptase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199299,0.0001125798,0.0003286478,0.0004206618,0.000281128,0.0004040593,0.0002484685,0.0003864725,0.001580956],"category_scores_gemma":[0.003446019,0.000136541,0.0001301181,0.0003631879,0.0004300339,0.0002693844,0.0002459304,0.0003248178,0.0001844584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002043005,"about_ca_system_score_gemma":0.0002519219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008325197,"about_ca_topic_score_gemma":0.002091143,"domain_scores_codex":[0.9990928,0.0002872565,0.00008676758,0.0002283973,0.000210821,0.00009386376],"domain_scores_gemma":[0.9968386,0.0008667544,0.001482877,0.0002605417,0.0003595036,0.0001916868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006630321,0.00008547644,0.9639355,0.000105868,0.00008724273,0.0007122688,0.0003313803,0.0001168716,0.01506551,0.0001164743,0.0002192088,0.01856113],"study_design_scores_gemma":[0.00003188328,0.0005083987,0.9879079,0.00003429197,0.00008065251,0.00609683,0.0002359732,0.0005921785,0.003185712,0.0002650041,0.001052693,0.000008388067],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986285,0.0005366741,0.000240281,0.00004307821,0.000003558303,0.000008888165,0.00004838879,0.00000394668,0.0004866053],"genre_scores_gemma":[0.9996202,0.00008877172,0.0001625902,0.0000284685,0.000005199095,0.000002458714,0.00003822473,0.000001555326,0.00005242164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001580956,"threshold_uncertainty_score":0.00634259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02077903399981855,"score_gpt":0.3186742726906186,"score_spread":0.2978952386908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}