{"id":"W2039657240","doi":"10.1038/onc.2010.373","title":"Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"BUB1; Biology; Spindle checkpoint; Adenomatous polyposis coli; Cancer research; Cell cycle checkpoint; Cell biology; Mitosis; Nocodazole; Spindle apparatus; Cell cycle; Chromosome segregation; Cancer; Colorectal cancer; Cell division; Cell; Genetics; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406773,0.0002751017,0.0002623769,0.0004895098,0.0003150495,0.0007750175,0.0002685981,0.0003592154,0.001238112],"category_scores_gemma":[0.0001560432,0.0002192151,0.0001835865,0.00023752,0.0004456322,0.0004488112,0.0002088202,0.0008002677,0.0004887564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004277006,"about_ca_system_score_gemma":0.0001718623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009724786,"about_ca_topic_score_gemma":0.001420474,"domain_scores_codex":[0.9999113,0.00001177112,0.00001164514,0.00001410015,0.00002854498,0.00002266713],"domain_scores_gemma":[0.9998277,0.00003353388,0.00003998427,0.00003429508,0.0000224404,0.00004210147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121847,0.00001185551,0.000162788,0.000006763461,0.000001729856,0.00003711994,0.00001038468,0.0000456496,0.9988837,0.0002781673,0.00002111151,0.0004285211],"study_design_scores_gemma":[0.00002137402,0.00007333289,0.002997463,0.000003041704,0.000009972527,0.0004800466,0.00003760923,0.001271761,0.9935398,0.0001292263,0.001432647,0.000003795844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960276,0.0005964447,0.001646651,0.0001411138,0.0000141831,0.00001131076,0.0002299093,0.00004386139,0.001289031],"genre_scores_gemma":[0.9963174,0.000442826,0.0008905262,0.00002618904,0.00000690773,0.00001229747,0.0002659091,0.00003148294,0.002006385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238112,"threshold_uncertainty_score":0.004141867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004273923838982444,"score_gpt":0.2197454948452765,"score_spread":0.215471571006294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}