{"id":"W2039721084","doi":"10.1385/endo:14:3:353","title":"Effects of Mutating Different Steroidogenic Factor-1 Protein Regions on Gene Regulation","year":2001,"lang":"en","type":"article","venue":"Endocrine","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council; National Institutes of Health; American Heart Association","keywords":"Steroidogenic factor 1; Steroidogenic acute regulatory protein; Gene; Protein kinase A; Promoter; Biology; Cyclic adenosine monophosphate; Transcriptional regulation; Molecular biology; Transcription factor; Receptor; Kinase; Genetics; Gene expression; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000281965,0.0001197808,0.0001304699,0.00002821576,0.00004616343,0.000008253414,0.00009305936,0.00004338047,0.00006029044],"category_scores_gemma":[0.00008125285,0.00009916913,0.00008632949,0.00004025118,0.00004626602,0.000002543603,0.00004526878,0.00005131703,0.00000710338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007639646,"about_ca_system_score_gemma":0.00001063306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004556937,"about_ca_topic_score_gemma":0.000004397169,"domain_scores_codex":[0.9992415,0.00005969893,0.000220543,0.0001944392,0.0001301561,0.0001537068],"domain_scores_gemma":[0.9995931,0.00003401807,0.00009682409,0.0001732441,0.00004587372,0.00005695655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001692302,0.000141407,0.0006447638,0.00003389378,0.00002525226,0.000009245727,0.00003108377,0.00001524035,0.9946519,0.0001526593,0.00003630733,0.00408909],"study_design_scores_gemma":[0.0007506723,0.0008754408,0.04344099,0.00003163412,0.000009492411,0.00001596032,0.00003403757,0.00001794712,0.9528302,0.0002597921,0.001622999,0.0001108193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983349,0.000148654,0.0006370113,0.0001724828,0.00006319552,0.0002151884,0.000006366069,0.00001288504,0.0004093524],"genre_scores_gemma":[0.9958404,0.00006304494,0.0001434162,0.00009042426,0.0001326579,0.00002902844,0.00004023316,0.00001215748,0.003648665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04279623,"threshold_uncertainty_score":0.4044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140526617735962,"score_gpt":0.2544862528790265,"score_spread":0.2430809867016669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}