{"id":"W2039730578","doi":"10.1182/blood-2009-07-234690","title":"Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Versus Arthritis; National Institute of General Medical Sciences; Nuffield Foundation","keywords":"Osteoclast; Biology; Cell biology; Cathepsin K; RANKL; Induced pluripotent stem cell; Macrophage colony-stimulating factor; Stem cell; Tartrate-resistant acid phosphatase; Embryoid body; Population; Bone resorption; Embryonic stem cell; Molecular biology; Endocrinology; Macrophage; Biochemistry; Activator (genetics); Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002331488,0.0000738989,0.00008934599,0.00001725219,0.000038858,0.00001243301,0.00002718141,0.00007239262,0.00003608168],"category_scores_gemma":[0.00002187812,0.00006670732,0.00002413862,0.00001884548,0.00006377654,0.000002770782,0.00004417052,0.00003629548,7.91908e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":2.371837e-7,"about_ca_system_score_gemma":0.00001027652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001789486,"about_ca_topic_score_gemma":0.0000526142,"domain_scores_codex":[0.9995955,0.00001862058,0.00009418264,0.0001664544,0.000058586,0.00006671187],"domain_scores_gemma":[0.9997447,0.00001030835,0.0000464502,0.0001170621,0.00002894184,0.00005258533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001701371,0.0001336674,0.03632879,0.00001576908,0.00003011384,2.288861e-7,0.0000329992,1.003379e-7,0.9630662,0.00009591044,0.0001070556,0.0001721196],"study_design_scores_gemma":[0.0006839935,0.0000315089,0.3676364,0.000004294347,0.00007721009,0.000001640928,0.0000135359,0.000002276214,0.6310788,0.0002085697,0.0002020187,0.00005974341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985909,0.00104755,0.00001799886,0.000009267354,0.00009011362,0.00006167069,0.00006821533,0.000009218096,0.0001050647],"genre_scores_gemma":[0.9994186,0.00003926138,0.0001806663,0.00001209278,0.0001085268,0.000005660831,0.0001564484,0.000007184143,0.00007151818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3319875,"threshold_uncertainty_score":0.2720246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00483332912171224,"score_gpt":0.1956851624934899,"score_spread":0.1908518333717777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}