{"id":"W2039730578","doi":"10.1182/blood-2009-07-234690","title":"Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Versus Arthritis; National Institute of General Medical Sciences; Nuffield Foundation","keywords":"Osteoclast; Biology; Cell biology; Cathepsin K; RANKL; Induced pluripotent stem cell; Macrophage colony-stimulating factor; Stem cell; Tartrate-resistant acid phosphatase; Embryoid body; Population; Bone resorption; Embryonic stem cell; Molecular biology; Endocrinology; Macrophage; Biochemistry; Activator (genetics); Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003032291,0.0003016769,0.0001797901,0.0002550242,0.0001156855,0.0003972211,0.0002399784,0.0002298538,0.00175122],"category_scores_gemma":[0.0002049668,0.0001491835,0.0001671971,0.0001773926,0.000222717,0.0001287283,0.0002610511,0.0005008588,0.001014521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001264322,"about_ca_system_score_gemma":0.0002268248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002821481,"about_ca_topic_score_gemma":0.0004350842,"domain_scores_codex":[0.9998528,0.00001772323,0.00002677239,0.0000248518,0.00006039738,0.00001736107],"domain_scores_gemma":[0.9999228,0.00001501307,0.00001308315,0.00001674877,0.00001911639,0.00001333048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073311,0.00003317309,0.0004267546,0.000110878,0.00000955088,0.0002760795,0.00005650035,0.0003926955,0.9830317,0.002581793,0.0006520664,0.01232133],"study_design_scores_gemma":[0.00004331754,0.0001088726,0.002429733,0.00003411231,0.00003857249,0.001162142,0.00004158781,0.00214579,0.9332021,0.0005122523,0.06027294,0.000008497746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7736523,0.009301816,0.1593017,0.0006060541,0.0003943485,0.0008050849,0.009701384,0.001384933,0.04485243],"genre_scores_gemma":[0.872907,0.008841935,0.0752084,0.0004327302,0.00007276562,0.0006276226,0.01293874,0.0002190435,0.02875168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00175122,"threshold_uncertainty_score":0.005858421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00483332912171224,"score_gpt":0.1956851624934899,"score_spread":0.1908518333717777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}