{"id":"W2039737850","doi":"10.1038/ncomms6202","title":"Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; Cure Brain Cancer Foundation; American Society of Clinical Oncology; Golfers Against Cancer; U.S. Department of Health and Human Services; National Institutes of Health; Ovarian Cancer Research Fund; Russell and Diana Hawkins Family Foundation; Conquer Cancer Foundation; RGK Foundation; National Center for Advancing Translational Sciences; Ontario Institute for Cancer Research; U.S. Department of Defense","keywords":"Drosha; Downregulation and upregulation; Dicer; microRNA; Cancer research; Biology; Biogenesis; Cell biology; Hypoxia (environmental); Tumor progression; Tumor microenvironment; Gene silencing; Small interfering RNA; Cancer; Transfection; Chemistry; RNA interference; Cell culture; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000231376,0.000113875,0.0001126112,0.00007482804,0.0001159972,0.00001198347,0.0005312811,0.0003102535,0.000008873179],"category_scores_gemma":[0.0004209728,0.0001061538,0.00007876674,0.0002058652,0.0001290642,0.000006186121,0.0002233837,0.0001379781,0.000007483904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001406563,"about_ca_system_score_gemma":0.00005078368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005008006,"about_ca_topic_score_gemma":0.00004474201,"domain_scores_codex":[0.9991288,0.0001868509,0.0002361274,0.0001902448,0.0001398215,0.0001181226],"domain_scores_gemma":[0.998148,0.00005233433,0.0002076601,0.001271236,0.000264403,0.00005635919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002045982,0.0001207568,0.00308311,0.00001645966,0.00002470043,3.095001e-8,0.00001608436,0.00001095713,0.99201,0.0006776395,0.001013123,0.003006684],"study_design_scores_gemma":[0.000448224,0.0001052848,0.2778107,0.00005792239,0.00004883471,0.000004538661,0.00001287263,0.001732022,0.6772274,0.000219437,0.04212405,0.0002088124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901021,0.006321514,0.0007228178,0.001223176,0.00006182367,0.0004423377,0.0000631725,0.00004244479,0.001020639],"genre_scores_gemma":[0.9885622,0.0001441902,0.009379585,0.00005948447,0.00006623494,0.0000386622,0.001696107,0.00001947776,0.00003410917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3147826,"threshold_uncertainty_score":0.4328827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025910846738783,"score_gpt":0.2838883417342167,"score_spread":0.2736292332668289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}