{"id":"W2039737850","doi":"10.1038/ncomms6202","title":"Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research; Cure Brain Cancer Foundation; American Society of Clinical Oncology; Golfers Against Cancer; U.S. Department of Health and Human Services; National Institutes of Health; Ovarian Cancer Research Fund; Russell and Diana Hawkins Family Foundation; Conquer Cancer Foundation; RGK Foundation; National Center for Advancing Translational Sciences; Ontario Institute for Cancer Research; U.S. Department of Defense","keywords":"Drosha; Downregulation and upregulation; Dicer; microRNA; Cancer research; Biology; Biogenesis; Cell biology; Hypoxia (environmental); Tumor progression; Tumor microenvironment; Gene silencing; Small interfering RNA; Cancer; Transfection; Chemistry; RNA interference; Cell culture; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001862948,0.0001659435,0.0002653869,0.000191225,0.0001987782,0.0004411347,0.0001316932,0.0002747361,0.002500051],"category_scores_gemma":[0.0002111589,0.0002058036,0.0002722735,0.0001063517,0.0002067209,0.0002157391,0.0003333503,0.0005644234,0.0006055128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368815,"about_ca_system_score_gemma":0.0002516542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004893769,"about_ca_topic_score_gemma":0.0008280211,"domain_scores_codex":[0.9997844,0.00003687374,0.00001605311,0.00004919306,0.00005041975,0.00006301375],"domain_scores_gemma":[0.9998391,0.00003138464,0.0000411855,0.00001861272,0.00001861769,0.0000510902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003115419,0.00002514366,0.0004394936,0.00004281432,0.000007694237,0.00008220714,0.0000140641,0.00006510758,0.9952428,0.0003058753,0.0003703481,0.003092898],"study_design_scores_gemma":[0.00003183887,0.0004964637,0.02414385,0.000009010937,0.00002254943,0.0004724333,0.00004109152,0.001401321,0.9634162,0.0002698719,0.009686651,0.000008854753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760282,0.006528251,0.008779324,0.0008257962,0.0002479374,0.00005563064,0.0007880501,0.0004362494,0.006310543],"genre_scores_gemma":[0.9936211,0.0009642161,0.001231907,0.0001441214,0.00003941999,0.00004035138,0.0003786093,0.00003780117,0.003542486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002500051,"threshold_uncertainty_score":0.008363545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025910846738783,"score_gpt":0.2838883417342167,"score_spread":0.2736292332668289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}