{"id":"W2039795057","doi":"10.3109/17482968.2012.686511","title":"Impaired proteasome function in sporadic amyotrophic lateral sclerosis","year":2012,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Amyotrophic lateral sclerosis; Proteasome; Spinal cord; Cerebellum; Motor neuron; Medicine; SOD1; Neurodegeneration; Biology; Pathology; Internal medicine; Neuroscience; Cell biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001348252,0.001197912,0.001672026,0.001102168,0.0004730385,0.0002679407,0.0006828813,0.000880716,0.002638001],"category_scores_gemma":[0.0001825785,0.001012786,0.0007307061,0.002389789,0.0005418101,0.001961255,0.0004879741,0.001819409,0.001750698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001511409,"about_ca_system_score_gemma":0.0002608966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002159456,"about_ca_topic_score_gemma":0.0000694432,"domain_scores_codex":[0.990665,0.0005898755,0.0017252,0.001479386,0.001965827,0.003574687],"domain_scores_gemma":[0.9958174,0.0001170265,0.0004199842,0.001560521,0.0003364987,0.001748563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002972281,0.00183763,0.7039146,0.0003456103,0.0003933702,0.0001192644,0.0009613169,0.00008351974,0.27288,0.000446236,0.001452308,0.0145939],"study_design_scores_gemma":[0.0058709,0.001273781,0.9862039,0.001127014,0.0002324619,0.0001236753,0.00003665648,0.0005949588,0.001539509,0.0004311668,0.001478727,0.001087263],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899884,0.001283053,0.00004723368,0.003547378,0.001043442,0.002710269,0.00004721256,0.0006177425,0.0007152194],"genre_scores_gemma":[0.9919772,0.000990391,0.0007857697,0.001721567,0.001761021,0.0007354146,0.0002002746,0.0003077337,0.0015206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2822893,"threshold_uncertainty_score":0.9992322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05287124286566975,"score_gpt":0.2704698479347955,"score_spread":0.2175986050691258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}