{"id":"W2039795057","doi":"10.3109/17482968.2012.686511","title":"Impaired proteasome function in sporadic amyotrophic lateral sclerosis","year":2012,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Amyotrophic lateral sclerosis; Proteasome; Spinal cord; Cerebellum; Motor neuron; Medicine; SOD1; Neurodegeneration; Biology; Pathology; Internal medicine; Neuroscience; Cell biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120699,0.0003416824,0.0002708154,0.0004984468,0.0001435195,0.000207866,0.00008870448,0.0002250637,0.000740409],"category_scores_gemma":[0.0002315625,0.0001335893,0.0001060121,0.0001791005,0.0002701882,0.0001360444,0.0001695753,0.0001548366,0.0001673651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001577451,"about_ca_system_score_gemma":0.00009462986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003222134,"about_ca_topic_score_gemma":0.000482584,"domain_scores_codex":[0.9998746,0.00002114824,0.00001706093,0.00002765792,0.00004258492,0.00001698872],"domain_scores_gemma":[0.999863,0.00001488527,0.00006658985,0.00001144611,0.00001806684,0.00002591423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008431775,0.00006196737,0.02310472,0.0001159889,0.00006694267,0.001245433,0.00009466503,0.0001278183,0.9706823,0.00007583963,0.00007984963,0.003501247],"study_design_scores_gemma":[0.0000947065,0.002024372,0.6791329,0.00004379052,0.0001862334,0.01609828,0.0002762449,0.001149648,0.297569,0.000778414,0.002630808,0.00001554741],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987683,0.0008830331,0.0001489904,0.00001181481,0.000002667268,0.000001448863,0.00004199682,0.00001182073,0.0001300348],"genre_scores_gemma":[0.9994065,0.0002468699,0.00009417886,0.000007472308,0.000002826097,0.000001886559,0.00007550435,0.000001836681,0.000163005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000740409,"threshold_uncertainty_score":0.002476931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05287124286566975,"score_gpt":0.2704698479347955,"score_spread":0.2175986050691258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}