{"id":"W2039824686","doi":"10.1042/bsr20140149","title":"The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex<i>in vitro</i>","year":2014,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Multiple Sclerosis Society of Canada","keywords":"SH3 domain; FYN; Myelin basic protein; Tyrosine kinase; Kinase; Proto-oncogene tyrosine-protein kinase Src; Chemistry; SH2 domain; Protein kinase domain; Biology; Biochemistry; Biophysics; Signal transduction; Myelin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001443801,0.0001636455,0.0001913372,0.00004974614,0.0001207492,0.00001802731,0.0005141068,0.0000534279,0.000001455147],"category_scores_gemma":[0.0002748494,0.00008104826,0.00006551689,0.000409871,0.0003753988,0.000006613925,0.0001753174,0.00006182324,3.265508e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002883192,"about_ca_system_score_gemma":0.0002174574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007862393,"about_ca_topic_score_gemma":0.0001922685,"domain_scores_codex":[0.9982578,0.0001271204,0.0004680541,0.0004276895,0.0004310463,0.0002882906],"domain_scores_gemma":[0.998085,0.00002758354,0.0004388686,0.00116833,0.0001768792,0.0001033114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003401124,0.0001593839,0.001114716,0.00002578293,0.000007313643,0.00001124814,0.0001559813,0.0003067334,0.9950435,0.00003725773,0.00009216172,0.00270586],"study_design_scores_gemma":[0.0002552607,0.0009773016,0.003293386,0.00007469067,0.0000126569,0.0000592805,0.0002429466,0.0003445637,0.9929997,0.00009994535,0.001513358,0.0001268585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956944,0.00006171071,0.0017803,0.001096915,0.00005271017,0.001193934,0.00001861123,0.000006012111,0.00009538078],"genre_scores_gemma":[0.9980365,0.000002795041,0.001482457,0.0001975322,0.00003442184,0.000148094,0.00001532249,0.00001492504,0.00006793124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002579002,"threshold_uncertainty_score":0.3305052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009915462824366734,"score_gpt":0.2460895104556201,"score_spread":0.2361740476312534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}