{"id":"W2039824686","doi":"10.1042/bsr20140149","title":"The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex<i>in vitro</i>","year":2014,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Multiple Sclerosis Society of Canada","keywords":"SH3 domain; FYN; Myelin basic protein; Tyrosine kinase; Kinase; Proto-oncogene tyrosine-protein kinase Src; Chemistry; SH2 domain; Protein kinase domain; Biology; Biochemistry; Biophysics; Signal transduction; Myelin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072753,0.0003106031,0.0001668288,0.00009137499,0.0001422753,0.0002058364,0.0001801441,0.0001726359,0.000787652],"category_scores_gemma":[0.00009354417,0.0001001809,0.0002322606,0.0001132302,0.0001456301,0.0001323965,0.0001987729,0.0003313295,0.000389693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511557,"about_ca_system_score_gemma":0.0001406168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009278358,"about_ca_topic_score_gemma":0.0009677749,"domain_scores_codex":[0.9999073,0.00001324027,0.000004886027,0.00002402992,0.00003003099,0.00002059414],"domain_scores_gemma":[0.9999298,0.00001262549,0.00002748294,0.000007630848,0.000006715883,0.00001572625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001995996,0.000007178423,0.0001907574,0.00001024535,0.000002099362,0.00002405036,0.000008923678,0.00001807449,0.9993328,0.00003692119,0.000009179119,0.000339665],"study_design_scores_gemma":[0.000003953895,0.0001148354,0.005919195,0.000003084934,0.000005955027,0.0003768838,0.00002094103,0.0006654494,0.9905426,0.00003574782,0.002308561,0.000002852287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926227,0.0006642145,0.005882401,0.00003388559,0.000007217121,0.00001273396,0.0001459573,0.00004004038,0.000590859],"genre_scores_gemma":[0.9892766,0.0004974335,0.007661294,0.00003406013,0.000008260856,0.00001673279,0.000821001,0.00001734461,0.001667237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009278358,"threshold_uncertainty_score":0.002634943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009915462824366734,"score_gpt":0.2460895104556201,"score_spread":0.2361740476312534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}