{"id":"W2039836118","doi":"10.1016/j.pain.2011.09.022","title":"Attenuation of rodent neuropathic pain by an orally active peptide, RAP-103, which potently blocks CCR2- and CCR5-mediated monocyte chemotaxis and inflammation","year":2011,"lang":"en","type":"article","venue":"Pain","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; AstraZeneca","keywords":"CCR2; Chemotaxis; Inflammation; Neuropathic pain; Monocyte; Medicine; Pharmacology; Neuroscience; Chemokine; Internal medicine; Receptor; Chemokine receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785942,0.0008531502,0.0004883861,0.0003527159,0.0001480111,0.0002241715,0.0003812134,0.0003856753,0.001513698],"category_scores_gemma":[0.0001251134,0.000180962,0.0003130725,0.0001698675,0.0003496455,0.0003181694,0.0001352707,0.001086371,0.0003417093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721548,"about_ca_system_score_gemma":0.00026952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003615146,"about_ca_topic_score_gemma":0.0007451227,"domain_scores_codex":[0.9998783,0.00002113042,0.00001289006,0.00001952817,0.000022527,0.0000456119],"domain_scores_gemma":[0.9998714,0.00001489433,0.00005065917,0.00001745068,0.00001032943,0.00003524193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005735857,0.0003980248,0.0001153393,0.0001954101,0.00001438943,0.00009366781,0.00001629158,0.0001616086,0.991223,0.000122193,0.00009455491,0.006991968],"study_design_scores_gemma":[0.0004269537,0.0175993,0.006437803,0.0000437923,0.00008330623,0.0009821436,0.00004103498,0.001016111,0.9708356,0.000102568,0.002413015,0.00001834291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926087,0.002250132,0.002947368,0.0001738653,0.00004225814,0.000120595,0.0004739195,0.0001944204,0.001188565],"genre_scores_gemma":[0.9864454,0.003281059,0.00692515,0.0001428774,0.00003913583,0.0002040742,0.0009009898,0.00002385342,0.002037404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513698,"threshold_uncertainty_score":0.005063772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02753811808760386,"score_gpt":0.2293254027519078,"score_spread":0.201787284664304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}