{"id":"W2039855223","doi":"10.2147/ndt.s5021","title":"Critical appraisal of the long-term impact of memantine in treatment of moderate to severe Alzheimer’s disease","year":2009,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Memantine; Disease; Apraxia; Dementia; Rivastigmine; Cognition; Cognitive decline; Caregiver burden; Agnosia; Psychiatry; Donepezil; Aphasia; Audiology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01595101,0.0009609295,0.003012948,0.001329374,0.0008826934,0.002064944,0.002273815,0.005166086,0.002902933],"category_scores_gemma":[0.03903139,0.0004187879,0.00311001,0.001095299,0.001139707,0.001625101,0.0006421822,0.004609627,0.0009688276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004097786,"about_ca_system_score_gemma":0.005828417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003129251,"about_ca_topic_score_gemma":0.005996551,"domain_scores_codex":[0.9934965,0.003050491,0.00166932,0.0001731484,0.001364125,0.000246404],"domain_scores_gemma":[0.9601786,0.01930464,0.005254705,0.0004994653,0.01306195,0.001700652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02540324,0.0002939034,0.001053785,0.1305213,0.002610839,0.00132451,0.0004389287,0.0005296094,0.002506353,0.003143631,0.3645419,0.467632],"study_design_scores_gemma":[0.01481711,0.009025474,0.01089067,0.1230077,0.009064978,0.00149509,0.0006974083,0.0008668959,0.002027788,0.00319824,0.8247054,0.0002032093],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.003755426,0.8915468,0.0003691614,0.0579595,0.03937181,0.001797026,0.0003215636,0.00004189328,0.004836773],"genre_scores_gemma":[0.05535519,0.7636585,0.003280822,0.07927008,0.08835243,0.002894342,0.0005027551,0.00003933594,0.006646602],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01595101,"threshold_uncertainty_score":0.08435798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03700982495800829,"score_gpt":0.3675863397229877,"score_spread":0.3305765147649794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}