{"id":"W2039864709","doi":"10.1002/jps.21988","title":"The functional roles of poly(ethylene glycol)‐lipid and lysolipid in the drug retention and release from lysolipid‐containing thermosensitive liposomes in vitro and in vivo","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"British Columbia Institute of Technology; Simon Fraser University; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Liposome; Dipalmitoylphosphatidylcholine; Chemistry; Ethylene glycol; In vivo; Bilayer; Drug; PEG ratio; Doxorubicin; Biophysics; Therapeutic index; Lipid bilayer; Pharmacology; Drug carrier; Drug delivery; Membrane; Biochemistry; Medicine; Internal medicine; Phosphatidylcholine; Organic chemistry; Phospholipid; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006190537,0.0003286115,0.000162044,0.0001825129,0.0001415498,0.0004084991,0.000193837,0.000352821,0.0008555065],"category_scores_gemma":[0.0004226074,0.0002941512,0.0002701217,0.00009173739,0.0004504189,0.0007126381,0.0001626669,0.0004094577,0.0002330405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000361877,"about_ca_system_score_gemma":0.0002310044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004219134,"about_ca_topic_score_gemma":0.0003219122,"domain_scores_codex":[0.999862,0.00004593212,0.00001592382,0.00002087802,0.00001826313,0.00003699838],"domain_scores_gemma":[0.9996762,0.0001366747,0.00006866114,0.00003239597,0.00003124116,0.00005486964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000893552,0.00002101636,0.0001419749,0.0000265438,0.000006668215,0.00003453841,0.00003303155,0.0000799312,0.9977054,0.0002114881,0.000008928999,0.0008368483],"study_design_scores_gemma":[0.00001480027,0.0001235697,0.00092054,0.0000025284,0.00001492958,0.00005146191,0.000009993991,0.0005298686,0.998114,0.00003183553,0.0001832485,0.000003353415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960946,0.001179599,0.002041728,0.00006384715,0.000008363078,0.0000118727,0.0001113993,0.00002220384,0.0004662521],"genre_scores_gemma":[0.9977221,0.0004111415,0.0007356056,0.00002189776,0.000004492847,0.00001440902,0.0001002055,0.0000136755,0.0009764942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008555065,"threshold_uncertainty_score":0.003273904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843901573656895,"score_gpt":0.2958296473135135,"score_spread":0.2773906315769445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}