{"id":"W2039864709","doi":"10.1002/jps.21988","title":"The functional roles of poly(ethylene glycol)‐lipid and lysolipid in the drug retention and release from lysolipid‐containing thermosensitive liposomes in vitro and in vivo","year":2009,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"British Columbia Institute of Technology; Simon Fraser University; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Liposome; Dipalmitoylphosphatidylcholine; Chemistry; Ethylene glycol; In vivo; Bilayer; Drug; PEG ratio; Doxorubicin; Biophysics; Therapeutic index; Lipid bilayer; Pharmacology; Drug carrier; Drug delivery; Membrane; Biochemistry; Medicine; Internal medicine; Phosphatidylcholine; Organic chemistry; Phospholipid; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001042976,0.00009614974,0.0001609844,0.00007133416,0.00009155675,0.00004610776,0.0001196237,0.00005400657,0.00000391942],"category_scores_gemma":[0.0001075214,0.00005238737,0.00003678985,0.0001460877,0.0003675839,0.00002806116,0.00003854606,0.0001958538,3.584396e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000918965,"about_ca_system_score_gemma":0.00005470177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003328092,"about_ca_topic_score_gemma":0.0001346792,"domain_scores_codex":[0.9989158,0.0002108858,0.0003101895,0.0001688953,0.0002202869,0.0001739731],"domain_scores_gemma":[0.9995459,0.0001643112,0.0001352021,0.00005478225,0.00003833438,0.00006149109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007773644,0.0000376463,0.009957868,0.000003376254,0.000007014619,0.000007162218,0.0003582008,0.000007874133,0.9617185,0.00003531594,0.00001117723,0.0270785],"study_design_scores_gemma":[0.00148907,0.0003339578,0.22295,0.00005279056,0.00003954913,0.0000983548,0.002226273,0.000301953,0.7713195,0.0004268526,0.0006549596,0.0001066882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940692,0.003305619,0.000004558717,0.00235312,0.0001077166,0.00008510733,0.000005474904,7.173243e-7,0.00006844269],"genre_scores_gemma":[0.9976938,0.001577943,0.00008226919,0.0003895696,0.0002461606,0.000001135777,8.984827e-7,0.000002271192,0.000005944807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2129921,"threshold_uncertainty_score":0.2136295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01843901573656895,"score_gpt":0.2958296473135135,"score_spread":0.2773906315769445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}