{"id":"W2039881906","doi":"10.1074/jbc.m112.428920","title":"Keratin 8 and 18 Loss in Epithelial Cancer Cells Increases Collective Cell Migration and Cisplatin Sensitivity through Claudin1 Up-regulation","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Canadian Institutes of Health Research","keywords":"Epithelial–mesenchymal transition; Biology; Cell biology; Cancer cell; Vimentin; Carcinogenesis; PI3K/AKT/mTOR pathway; Protein kinase B; Signal transduction; Cancer research; Intermediate filament; Keratin; Keratin 8; Cell growth; Cell; Cancer; Metastasis; Immunology; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007053527,0.0002508292,0.0002998924,0.0001878381,0.0001691127,0.0002367982,0.0001302905,0.00022922,0.00136419],"category_scores_gemma":[0.00007617101,0.0001367923,0.0002496292,0.0001633379,0.0001754235,0.0002067426,0.0001952092,0.0006063002,0.0002942078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002142733,"about_ca_system_score_gemma":0.0002030123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006055667,"about_ca_topic_score_gemma":0.0006798141,"domain_scores_codex":[0.9998556,0.00001704412,0.00001597444,0.00003094709,0.00004584872,0.0000345222],"domain_scores_gemma":[0.9999279,0.000007582621,0.00002287883,0.00001112117,0.000009322774,0.00002122595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000707373,0.00003686978,0.000220638,0.00003924655,0.000006317235,0.00004288773,0.00001390293,0.00003728419,0.9985002,0.00004243321,0.000047984,0.000941453],"study_design_scores_gemma":[0.00001926088,0.0003495689,0.009223952,0.000006294449,0.00002353739,0.0003582922,0.00003744561,0.0007881794,0.9863582,0.00003900788,0.00279168,0.000004472039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963326,0.001244275,0.001191831,0.00007638089,0.00002480356,0.00002460582,0.0001894347,0.00008245829,0.0008334468],"genre_scores_gemma":[0.9967626,0.000636876,0.0008529717,0.00003471776,0.000003862561,0.00003781686,0.0002136776,0.00001011485,0.001447216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00136419,"threshold_uncertainty_score":0.004563689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01766231673477355,"score_gpt":0.2718846402553161,"score_spread":0.2542223235205425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}