{"id":"W2039905887","doi":"10.1101/pdb.top069765","title":"Transgenic Mouse Models—A Seminal Breakthrough in Oncogene Research","year":2013,"lang":"en","type":"review","venue":"Cold Spring Harbor Protocols","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Transgene; Genetically modified mouse; Carcinogenesis; Oncogene; Gain of function; Biology; Function (biology); Suppressor; Cancer; Metastasis; Computational biology; Cancer research; Cell biology; Gene; Phenotype; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007595693,0.000503676,0.0009767348,0.0002855012,0.0001252831,0.0001459679,0.0008460064,0.0005689777,0.00006115041],"category_scores_gemma":[0.00005924885,0.0004524202,0.0004229698,0.0004349609,0.0001416527,0.00001434251,0.0003606821,0.0007817693,0.0001619443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003819697,"about_ca_system_score_gemma":0.001294606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006730485,"about_ca_topic_score_gemma":0.0002613697,"domain_scores_codex":[0.9963084,0.0004368252,0.0006059805,0.001033984,0.00058242,0.001032397],"domain_scores_gemma":[0.9982208,0.0000433207,0.0001343089,0.001141149,0.000176577,0.0002838327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007521183,0.003163114,0.00009771004,0.06542374,0.001958123,0.0003170941,0.00008695411,0.00007252893,0.05303104,0.002589223,0.007911379,0.864597],"study_design_scores_gemma":[0.0009512991,0.000448848,0.000002417222,0.00455016,0.00003700635,0.000002466205,0.000002009843,0.00001019252,0.01213528,0.00001708367,0.9814264,0.000416883],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002040156,0.8795855,0.00006982533,0.00001121723,0.00002468261,0.1194232,0.0001023701,0.00002497449,0.0005542313],"genre_scores_gemma":[0.0001162156,0.6537766,0.000276804,0.000007247811,0.0002231261,0.3444395,0.00002640305,0.0001081769,0.001025889],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.973515,"threshold_uncertainty_score":0.9997928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2092022179098973,"score_gpt":0.4640379351191913,"score_spread":0.254835717209294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}