{"id":"W2039919483","doi":"10.1002/bdd.301","title":"Pharmacokinetics and metabolism of the novel synthetic <i>C</i>‐nucleoside, 1‐(2‐deoxy‐<i>β</i>‐D‐ribofuranosyl)‐2,4‐difluoro‐ 5‐iodobenzene: a potential mimic of 5‐iodo‐2′‐deoxyuridine","year":2002,"lang":"en","type":"article","venue":"Biopharmaceutics & Drug Disposition","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Lipophilicity; Glucuronide; Pharmacokinetics; Metabolite; Phosphorolysis; Bioavailability; Metabolism; Biochemistry; Purine nucleoside phosphorylase; Stereochemistry; Pharmacology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578733,0.000276061,0.0002026281,0.0001040736,0.0001013864,0.0003723729,0.000171856,0.0002681007,0.0007262148],"category_scores_gemma":[0.0003984424,0.0002169876,0.0001643778,0.0001064468,0.0002659824,0.0004401168,0.0000607709,0.0004008521,0.0003215696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004633463,"about_ca_system_score_gemma":0.0003848695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001764766,"about_ca_topic_score_gemma":0.001110336,"domain_scores_codex":[0.9999193,0.00002500511,0.000003117994,0.0000226029,0.00001197337,0.0000181086],"domain_scores_gemma":[0.9998723,0.00003147149,0.00003804686,0.00001448018,0.00001270024,0.00003094976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0150859,0.0005898559,0.00349076,0.0001017148,0.00006488439,0.0002188671,0.0001692124,0.001308221,0.9522595,0.0006100915,0.0006168796,0.02548415],"study_design_scores_gemma":[0.0004849164,0.03020687,0.03878292,0.000016676,0.0002613731,0.001952287,0.0001939596,0.01759192,0.9010521,0.0003756181,0.009017448,0.00006394687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947191,0.001425972,0.002548129,0.00005953536,0.00002349063,0.00002382926,0.0002660069,0.00005695458,0.0008769294],"genre_scores_gemma":[0.996396,0.0008285315,0.0009977075,0.00004937713,0.00002362705,0.00003465713,0.000476772,0.00002270286,0.001170622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764766,"threshold_uncertainty_score":0.003508985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188717152952399,"score_gpt":0.2468813556342977,"score_spread":0.2349941841047737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}