{"id":"W2039919483","doi":"10.1002/bdd.301","title":"Pharmacokinetics and metabolism of the novel synthetic <i>C</i>‐nucleoside, 1‐(2‐deoxy‐<i>β</i>‐D‐ribofuranosyl)‐2,4‐difluoro‐ 5‐iodobenzene: a potential mimic of 5‐iodo‐2′‐deoxyuridine","year":2002,"lang":"en","type":"article","venue":"Biopharmaceutics & Drug Disposition","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Lipophilicity; Glucuronide; Pharmacokinetics; Metabolite; Phosphorolysis; Bioavailability; Metabolism; Biochemistry; Purine nucleoside phosphorylase; Stereochemistry; Pharmacology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000219333,0.0003275347,0.0003344699,0.00009144412,0.000133984,0.00003643433,0.0004733457,0.0002097928,0.00004400934],"category_scores_gemma":[0.00005662978,0.0002666459,0.0002933426,0.0003024726,0.0005110558,0.00001396487,0.0004061817,0.0002757387,0.000004214059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001464493,"about_ca_system_score_gemma":0.00003153173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002259873,"about_ca_topic_score_gemma":0.000002761259,"domain_scores_codex":[0.9979076,0.0001385199,0.0005311733,0.0005091582,0.0004863275,0.0004271669],"domain_scores_gemma":[0.9987429,0.00002272039,0.0002629522,0.000531127,0.0002463774,0.0001938842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001812904,0.0004493373,0.00007982795,0.0001839955,0.0001512674,0.000002664912,0.00006614941,0.00004314358,0.9957716,0.0001545737,0.0006261278,0.002290041],"study_design_scores_gemma":[0.001743165,0.00006645809,0.0008924321,0.00006448433,0.0003531694,0.00005805014,0.00002990069,0.00174325,0.983649,0.00003800331,0.01107685,0.000285243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866565,0.01026835,0.0006248787,0.001094881,0.0002940947,0.0005206074,0.0003300905,0.00001588459,0.0001946449],"genre_scores_gemma":[0.994952,0.003526513,0.0005001122,0.0004173061,0.0001914955,0.00002342764,0.00007580386,0.00005207509,0.0002612202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01212259,"threshold_uncertainty_score":0.9999786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188717152952399,"score_gpt":0.2468813556342977,"score_spread":0.2349941841047737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}