{"id":"W2039926285","doi":"10.1210/me.2002-0154","title":"Attenuation of Glucocorticoid Signaling through Targeted Degradation of p300 via the 26S Proteasome Pathway","year":2002,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; MG132; Sodium butyrate; HDAC4; Glucocorticoid receptor; Coactivator; P300-CBP Transcription Factors; Nuclear receptor coactivator 2; Glucocorticoid; Proteasome; Proteasome inhibitor; Cell biology; Transcription factor; Histone deacetylase; Endocrinology; Histone; Biochemistry; Gene; Histone Acetyltransferases","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007586846,0.0001545755,0.0002064316,0.00004718496,0.00004616272,0.000003886664,0.0001855988,0.0001613734,0.00003144506],"category_scores_gemma":[0.00008335189,0.0001203619,0.0001408857,0.0001619225,0.0001177304,0.000005636125,0.00007585695,0.0001433742,0.00001634315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009886292,"about_ca_system_score_gemma":0.00002477249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002565768,"about_ca_topic_score_gemma":0.000001152357,"domain_scores_codex":[0.9987732,0.0002006124,0.0003353154,0.0002664569,0.0001549002,0.0002695623],"domain_scores_gemma":[0.999194,0.00002220609,0.0002425459,0.0004025689,0.0001130795,0.00002559731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004041921,0.00008645172,0.0005605702,0.00003174251,0.0001336547,0.00001175023,0.000063443,0.0008506907,0.9943949,0.0007790553,0.00003962794,0.00300771],"study_design_scores_gemma":[0.0005857601,0.0004821418,0.0002564536,0.00001296812,0.00004468431,0.00005607557,0.00002824656,0.0007343963,0.9966329,0.0001405725,0.0009055504,0.0001202875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786985,0.00460739,0.01523315,0.0002655507,0.0001080583,0.0005403612,0.000005398069,0.00001239256,0.0005292077],"genre_scores_gemma":[0.9985217,0.0001714373,0.0009019554,0.0001114715,0.00002992309,0.00004553682,0.00006590366,0.00002296097,0.0001290976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01982322,"threshold_uncertainty_score":0.4908218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084366739826911,"score_gpt":0.2229575750543205,"score_spread":0.2121139076560513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}