{"id":"W2039937945","doi":"10.1158/0008-5472.sabcs12-p6-11-06","title":"Abstract P6-11-06: A phase Ib study of LCL161, an oral inhibitor of apoptosis (IAP) antagonist, in combination with weekly paclitaxel in patients with advanced solid tumors","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; Neutropenia; Paclitaxel; Pharmacokinetics; Pharmacology; Inhibitor of apoptosis; Pharmacodynamics; Cancer; Febrile neutropenia; Internal medicine; Cytokine release syndrome; Nausea; Oncology; Gastroenterology; Chemotherapy; Apoptosis; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001248099,0.001342444,0.001586893,0.0004546224,0.0005215036,0.0009569023,0.0008408821,0.001022285,0.00262147],"category_scores_gemma":[0.0005547046,0.0005483967,0.001020488,0.0005097485,0.0009478474,0.0006631491,0.000390688,0.004303223,0.0009145156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007940956,"about_ca_system_score_gemma":0.001877837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147516,"about_ca_topic_score_gemma":0.001711527,"domain_scores_codex":[0.9996622,0.0001287133,0.00002402765,0.00006065564,0.00004972277,0.00007466401],"domain_scores_gemma":[0.9994604,0.0000650394,0.00008295573,0.00004221001,0.00003934702,0.0003100646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.420184,0.1707468,0.01624854,0.001334129,0.001557878,0.000979283,0.0006651555,0.005170829,0.1910376,0.0004194939,0.005925219,0.1857311],"study_design_scores_gemma":[0.2805014,0.6842524,0.01500621,0.00004395118,0.0003874429,0.0006815863,0.00007217219,0.00173447,0.01393043,0.0001220705,0.003235888,0.00003196604],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937283,0.001189771,0.000577017,0.0003543451,0.00006477879,0.001995809,0.0006561559,0.00009814242,0.001335615],"genre_scores_gemma":[0.9895086,0.001558962,0.00202061,0.000457407,0.0001310936,0.001613236,0.002002645,0.00002815138,0.002679339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00262147,"threshold_uncertainty_score":0.008769691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864178216342169,"score_gpt":0.3668788085511367,"score_spread":0.338237026387715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}