{"id":"W2039955490","doi":"10.1371/journal.ppat.1000608","title":"Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; W. Garfield Weston Foundation","keywords":"Endoplasmic reticulum; Interactome; Cell biology; Glycan; Biology; Computational biology; Genetics; Glycoprotein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262635,0.0001681029,0.0001256445,0.0005900371,0.0001797731,0.0001790187,0.00009820545,0.0001990299,0.0006368816],"category_scores_gemma":[0.0002027543,0.00006557429,0.0001468194,0.0003093277,0.0001354761,0.0001480028,0.0002038333,0.0001671613,0.0001521268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001447573,"about_ca_system_score_gemma":0.00008348943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004464492,"about_ca_topic_score_gemma":0.0009449376,"domain_scores_codex":[0.9998999,0.00001659844,0.000007315,0.00003002495,0.00002988369,0.00001627296],"domain_scores_gemma":[0.9998386,0.00004607811,0.00005087639,0.00001513696,0.00002177564,0.00002745811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001949452,0.00001419123,0.006182788,0.00003096547,0.00002153512,0.0001756232,0.00002792784,0.00003526601,0.9914114,0.00008971418,0.00003024167,0.001785426],"study_design_scores_gemma":[0.00001182244,0.0003614611,0.5051366,0.00000761485,0.0001336099,0.003867336,0.0002036527,0.003472991,0.4831785,0.0003671548,0.003245949,0.00001334884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976737,0.0005449152,0.0009834192,0.00001763324,0.000001667557,0.000005297631,0.0002495763,0.00001134181,0.0005124783],"genre_scores_gemma":[0.9956571,0.0002832197,0.002281617,0.00002457214,0.000004135996,0.00001209118,0.001033338,0.000004570775,0.0006993797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006368816,"threshold_uncertainty_score":0.002130568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0312704654985728,"score_gpt":0.3143235680509364,"score_spread":0.2830531025523635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}