{"id":"W2039967958","doi":"10.1021/bi800964q","title":"The Dual Histidine Motif in the Active Site of Pin1 Has a Structural Rather than Catalytic Role","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Schulich School of Medicine and Dentistry; Schulich School of Medicine and Dentistry, Western University","keywords":"Motif (music); Histidine; Structural motif; Chemistry; PIN1; Active site; Dual role; Catalysis; Biochemistry; Combinatorial chemistry; Isomerase; Enzyme; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000870568,0.0003658993,0.0003024882,0.00008504283,0.0002008176,0.0003612488,0.0003703478,0.0006218568,0.003033461],"category_scores_gemma":[0.0001099249,0.0001404911,0.0003382834,0.00007618395,0.0003257481,0.0003392682,0.0003368797,0.0005722474,0.001252663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002352031,"about_ca_system_score_gemma":0.0001549177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002554919,"about_ca_topic_score_gemma":0.0002479288,"domain_scores_codex":[0.9999229,0.000007447733,0.000005322066,0.00002928158,0.00002085468,0.00001412372],"domain_scores_gemma":[0.9999175,0.00001198,0.00002394527,0.000009359155,0.000007126034,0.00003006462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002282981,0.00002804839,0.0007127532,0.00008710862,0.000008964344,0.0003825962,0.00001466151,0.00009733604,0.9953443,0.0004859949,0.00007556705,0.002534279],"study_design_scores_gemma":[0.00005560699,0.0002597398,0.01211562,0.00001513224,0.0000238353,0.002218571,0.00005696358,0.002063958,0.9782425,0.0002974551,0.004631745,0.00001892783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874113,0.001038878,0.008562724,0.0002810014,0.0001023759,0.00002550472,0.000283221,0.0001053599,0.002189582],"genre_scores_gemma":[0.9958866,0.0001342031,0.002474983,0.00008652741,0.0000109523,0.000007036195,0.0002245089,0.00001005997,0.00116515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003033461,"threshold_uncertainty_score":0.01014793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351064206595213,"score_gpt":0.228962788900917,"score_spread":0.2154521468349649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}