{"id":"W2039967958","doi":"10.1021/bi800964q","title":"The Dual Histidine Motif in the Active Site of Pin1 Has a Structural Rather than Catalytic Role","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Schulich School of Medicine and Dentistry; Schulich School of Medicine and Dentistry, Western University","keywords":"Motif (music); Histidine; Structural motif; Chemistry; PIN1; Active site; Dual role; Catalysis; Biochemistry; Combinatorial chemistry; Isomerase; Enzyme; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378483,0.0001732435,0.0001217283,0.00001115645,0.0001693049,0.00001739978,0.0003560654,0.0001276318,0.00001015651],"category_scores_gemma":[0.0002314314,0.0001123061,0.0001125668,0.0001055494,0.000434941,0.000002708507,0.0001097444,0.0001324916,0.000004208145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002665089,"about_ca_system_score_gemma":0.0001918081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007293744,"about_ca_topic_score_gemma":0.00001902793,"domain_scores_codex":[0.9990102,0.00005345177,0.000207357,0.0002888517,0.000201846,0.0002382646],"domain_scores_gemma":[0.9990973,0.00004583188,0.0001167766,0.0006200703,0.00006579134,0.00005426969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001713093,0.00004718331,0.004556716,0.00001682725,0.00003525689,0.00001645883,0.0003925279,0.0000234657,0.9933212,0.000006921655,0.001244667,0.0001674905],"study_design_scores_gemma":[0.0004305826,0.00005001716,0.00711064,0.00001569932,0.00001536761,0.00007429247,0.0003428147,0.00005845583,0.9908425,0.0000499882,0.0008660628,0.0001436131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976758,0.00131239,0.000006178499,0.0001766608,0.00005132238,0.0001470943,0.00009724613,0.000007761353,0.0005254895],"genre_scores_gemma":[0.9990074,0.00001822146,0.0000312113,0.00007045482,0.0002195872,0.00002724685,0.0001657587,0.00001814724,0.0004419948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553924,"threshold_uncertainty_score":0.457971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351064206595213,"score_gpt":0.228962788900917,"score_spread":0.2154521468349649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}