{"id":"W2039971816","doi":"10.1593/neo.06442","title":"Ubiquitin Pathway in VHL Cancer Syndrome","year":2006,"lang":"en","type":"review","venue":"Neoplasia","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"","keywords":"Ubiquitin ligase; Biology; Ubiquitin; Hypoxia-inducible factors; Carcinogenesis; Transcription factor; Cancer research; Oxygen tension; HIF1A; Cellular adaptation; Mdm2; Cancer; Cell biology; Germline mutation; Genetics; Gene; Mutation; Angiogenesis; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001510474,0.0004810074,0.001170497,0.0001425897,0.00004102036,0.0000317229,0.0003498352,0.0007157152,0.00009235344],"category_scores_gemma":[0.00002505178,0.0004388093,0.0004401945,0.0002376955,0.00005680107,0.000002840111,0.0001288401,0.00034201,0.00006293548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000705033,"about_ca_system_score_gemma":0.0007910824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003611548,"about_ca_topic_score_gemma":0.001721722,"domain_scores_codex":[0.9980035,0.000111883,0.0005311705,0.0006887152,0.000174029,0.0004906317],"domain_scores_gemma":[0.999081,0.00001567096,0.0002328726,0.0005301166,0.00003782009,0.000102497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007862363,0.00005537766,0.0000146857,0.002853066,0.00007566877,0.00003268848,0.000009442782,0.000004713308,0.0001842549,0.00003847839,0.01821168,0.9785121],"study_design_scores_gemma":[0.0003101626,0.00004644347,0.00004681976,0.001616103,0.0001185977,0.0002288276,0.000003218336,3.146756e-7,0.0001326125,0.000008491308,0.9970262,0.000462209],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007212813,0.9931366,0.000008645898,0.00001185426,0.002128515,0.0005129632,0.0003205623,0.00001877818,0.003140822],"genre_scores_gemma":[0.00008834266,0.989423,0.00006501526,0.00008713123,0.002441078,0.0003947176,0.0007399079,0.00009388349,0.006666858],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9788145,"threshold_uncertainty_score":0.9998063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195573872817134,"score_gpt":0.2994778235278685,"score_spread":0.2799204362461551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}