{"id":"W2039971816","doi":"10.1593/neo.06442","title":"Ubiquitin Pathway in VHL Cancer Syndrome","year":2006,"lang":"en","type":"review","venue":"Neoplasia","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"","keywords":"Ubiquitin ligase; Biology; Ubiquitin; Hypoxia-inducible factors; Carcinogenesis; Transcription factor; Cancer research; Oxygen tension; HIF1A; Cellular adaptation; Mdm2; Cancer; Cell biology; Germline mutation; Genetics; Gene; Mutation; Angiogenesis; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711152,0.0006684918,0.0008994095,0.001602192,0.0002732437,0.0004225407,0.0005050147,0.0009759217,0.002789152],"category_scores_gemma":[0.0002604178,0.0001487443,0.0002427443,0.001070108,0.0003123864,0.0005667738,0.0004006894,0.0009266315,0.001933756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004972564,"about_ca_system_score_gemma":0.0004623384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009781823,"about_ca_topic_score_gemma":0.001704299,"domain_scores_codex":[0.9999348,0.00000947377,0.000008920082,0.00001414024,0.00002227756,0.00001038298],"domain_scores_gemma":[0.999944,0.00002055856,0.00001027816,0.000002337935,0.00001280377,0.00001008463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007457311,0.00005383505,0.0005405475,0.003791684,0.00005462258,0.003209772,0.00005724681,0.0003007269,0.002141042,0.002387837,0.02976444,0.9576238],"study_design_scores_gemma":[0.00002860267,0.00006967169,0.00221833,0.001062602,0.00008322189,0.03116163,0.00006501781,0.00009847205,0.001056214,0.001749726,0.9623905,0.00001590716],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007556714,0.9948704,0.0003640441,0.0004112722,0.0002875372,0.000006237419,0.00002131474,0.00002734091,0.003256223],"genre_scores_gemma":[0.005011651,0.989844,0.0003859063,0.0005228852,0.0002894874,0.000008981745,0.00007116765,0.000004243077,0.003861706],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002789152,"threshold_uncertainty_score":0.00933063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195573872817134,"score_gpt":0.2994778235278685,"score_spread":0.2799204362461551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}