{"id":"W2040014098","doi":"10.1038/nature02122","title":"A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance","year":2003,"lang":"en","type":"article","venue":"Nature","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1189,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cystic Fibrosis Canada; National Institutes of Health; Cystic Fibrosis Foundation; National Science Foundation","keywords":"Biofilm; Periplasmic space; Pseudomonas aeruginosa; Microbiology; Antibiotics; Tobramycin; Biology; Antibiotic resistance; Bacteria; Antimicrobial; Mutant; Genetics; Gene; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227776,0.0003419117,0.0002319645,0.0003797938,0.0002823462,0.0003083525,0.000495706,0.001005691,0.000997667],"category_scores_gemma":[0.000334003,0.0001946444,0.0002054348,0.0002029291,0.0005096775,0.0002982427,0.0003535495,0.0008720688,0.0003130399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003675221,"about_ca_system_score_gemma":0.0002326241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000553459,"about_ca_topic_score_gemma":0.0004783351,"domain_scores_codex":[0.9998133,0.00002059319,0.00000925653,0.00002521567,0.000100341,0.00003130901],"domain_scores_gemma":[0.9998337,0.00004735891,0.0000373458,0.00002518451,0.00002307519,0.00003332786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003292626,0.00003048398,0.0002387813,0.00001339687,0.00000324364,0.0003521579,0.00001385167,0.0001408098,0.9945394,0.002482979,0.0001375359,0.002014387],"study_design_scores_gemma":[0.00005625541,0.0003256633,0.01857997,0.00001974086,0.0000502795,0.00778333,0.000141396,0.00920526,0.9438196,0.008355655,0.01162723,0.00003571776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729707,0.002434666,0.01665612,0.002131832,0.0001844944,0.0000324866,0.000267351,0.0002753582,0.005046978],"genre_scores_gemma":[0.995402,0.0006435399,0.002531482,0.0001588053,0.00003059363,0.0000150463,0.00007229371,0.00002174749,0.001124476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005691,"threshold_uncertainty_score":0.003337502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006299672749998503,"score_gpt":0.2338027798573127,"score_spread":0.2275031071073141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}