{"id":"W2040025293","doi":"10.1021/ja5114672","title":"Eight-Membered Ring-Containing Jadomycins: Implications for Non-enzymatic Natural Products Biosynthesis","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acadia University; Institute for Marine Biosciences; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; California HIV/AIDS Research Program","keywords":"Chemistry; Biosynthesis; Ring (chemistry); Derivatization; Enzyme; Acylation; Stereochemistry; Ornithine; Streptomyces; Amino acid; Biochemistry; Organic chemistry; Bacteria; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005694118,0.0001937613,0.0006006677,0.00003149596,0.0001164607,0.0000338495,0.0003839412,0.00006382992,0.000004569174],"category_scores_gemma":[0.002088803,0.0001069801,0.000630273,0.000517381,0.0002995624,0.0001125447,0.00009841251,0.0004440518,0.00000281969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003045861,"about_ca_system_score_gemma":0.0002978521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001924591,"about_ca_topic_score_gemma":4.82452e-7,"domain_scores_codex":[0.9986306,0.00003457754,0.0005189347,0.0002331158,0.0002683113,0.0003144643],"domain_scores_gemma":[0.9976084,0.0002231427,0.0008547929,0.0003811171,0.0007500437,0.0001825574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003001644,0.0001163626,0.0006938599,0.0000700071,0.0002469769,6.516652e-7,0.0003159849,0.000001170297,0.9595698,0.000008839873,0.03471602,0.003960148],"study_design_scores_gemma":[0.001235552,0.000263827,0.004014177,0.0002181938,0.0004814167,0.0003153065,0.0007135208,0.0001628618,0.9840343,0.0002183615,0.00813034,0.0002121495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9484753,0.0003396689,0.00004674036,0.05038654,0.0002529955,0.0004001642,0.00001331607,0.00001675796,0.00006853492],"genre_scores_gemma":[0.977163,0.00003462331,0.01948047,0.002063558,0.00105525,0.000001735841,0.000003160749,0.00002654727,0.0001716257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04832298,"threshold_uncertainty_score":0.4362523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584703809250399,"score_gpt":0.2825022781246469,"score_spread":0.2566552400321429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}