{"id":"W2040025293","doi":"10.1021/ja5114672","title":"Eight-Membered Ring-Containing Jadomycins: Implications for Non-enzymatic Natural Products Biosynthesis","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acadia University; Institute for Marine Biosciences; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; California HIV/AIDS Research Program","keywords":"Chemistry; Biosynthesis; Ring (chemistry); Derivatization; Enzyme; Acylation; Stereochemistry; Ornithine; Streptomyces; Amino acid; Biochemistry; Organic chemistry; Bacteria; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009313714,0.0001755141,0.0001056743,0.0001343754,0.0001067988,0.0003033246,0.0001086514,0.0001257798,0.0005448312],"category_scores_gemma":[0.0001068354,0.00005627189,0.00007421142,0.0001461378,0.000240667,0.0002739546,0.0001696018,0.0002454752,0.0001170602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002731419,"about_ca_system_score_gemma":0.0002447634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005101538,"about_ca_topic_score_gemma":0.001252668,"domain_scores_codex":[0.9999794,0.000005267075,0.000001525212,0.000004201089,0.000003243717,0.000006439867],"domain_scores_gemma":[0.9999516,0.0000105294,0.00001230097,0.000005915796,0.000004893201,0.00001483053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002605821,0.00004225485,0.001895177,0.0001251888,0.000004256395,0.0003478532,0.00006246852,0.000736989,0.9743401,0.002879966,0.00004910187,0.01925618],"study_design_scores_gemma":[0.0000794245,0.001550468,0.02877662,0.00009729047,0.00003224701,0.002372458,0.0004153862,0.002522047,0.9248002,0.004518406,0.03480032,0.00003516984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776258,0.01201888,0.005230645,0.0003559843,0.00002830082,0.0000240022,0.0002253327,0.00003233122,0.004458676],"genre_scores_gemma":[0.9907435,0.003598979,0.004493854,0.0000407213,0.00001022901,0.000007433764,0.000134485,0.000003456428,0.000967359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005448312,"threshold_uncertainty_score":0.001981795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584703809250399,"score_gpt":0.2825022781246469,"score_spread":0.2566552400321429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}