{"id":"W2040062889","doi":"10.1136/heart.86.6.706","title":"Tetrahydrobiopterin attenuates cholesterol induced coronary hyperreactivity to endothelin","year":2001,"lang":"en","type":"letter","venue":"Heart","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"Chinese University of Hong Kong; University Grants Committee","keywords":"Nitric oxide; Tetrahydrobiopterin; Endothelial dysfunction; Endocrinology; Internal medicine; Endothelium; Endothelin receptor; Nitric oxide synthase; Endothelin 1; Medicine; Vasoconstriction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000242118,0.0005638535,0.0009992454,0.0003875823,0.00007721678,0.00004225035,0.0001817961,0.0008969084,0.0004433496],"category_scores_gemma":[0.000128786,0.000503074,0.0002949118,0.0002736407,0.00004799461,0.00008734535,0.0001002695,0.002244883,0.003958562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839258,"about_ca_system_score_gemma":0.0001329939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004426759,"about_ca_topic_score_gemma":0.00001389388,"domain_scores_codex":[0.9973723,0.0001440326,0.000402176,0.0007677662,0.0005133045,0.0008004708],"domain_scores_gemma":[0.9983263,0.0003094316,0.00009184799,0.0009176855,0.00007674624,0.0002779683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000154643,0.0001543865,0.009924835,0.0003003694,0.0001194659,0.002350554,0.00006727676,8.215906e-7,0.1576079,1.474568e-7,0.8220527,0.007266898],"study_design_scores_gemma":[0.001411764,0.0007194526,0.01671674,0.0004929559,0.0001678463,0.003053701,0.00001051713,0.000009760371,0.01918072,0.000008686951,0.9577128,0.0005150983],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.63341,0.00008574992,0.0000124906,0.3614894,0.0006704631,0.001117198,0.00006530486,0.0002254813,0.002923903],"genre_scores_gemma":[0.2015509,0.0000502243,0.0004399571,0.7772114,0.006344649,0.0001646977,0.0002046907,0.0001860442,0.01384736],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4318591,"threshold_uncertainty_score":0.9997421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0373021539949696,"score_gpt":0.2918261663918739,"score_spread":0.2545240123969043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}