{"id":"W2040063892","doi":"10.1158/1055-9965.epi-08-0546","title":"Reproductive and Hormonal Factors, and Ovarian Cancer Risk for <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers: Results from the International <i>BRCA1/2</i> Carrier Cohort Study","year":2009,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Cancer Research UK","keywords":"Ovarian cancer; Hazard ratio; Medicine; Oncology; Gynecology; BRCA mutation; Population; Confidence interval; Cancer; Obstetrics; Proportional hazards model; Cohort; Internal medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002294331,0.0003366992,0.000397054,0.0000583447,0.000383052,0.00004638141,0.0002215983,0.0002795758,0.00001067305],"category_scores_gemma":[0.001433302,0.0002721588,0.0001059426,0.0001098553,0.0003850234,0.00003963285,0.0001227224,0.0001965315,2.270176e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001748973,"about_ca_system_score_gemma":0.0002136312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002298152,"about_ca_topic_score_gemma":0.002241995,"domain_scores_codex":[0.9968672,0.0006005389,0.0006527381,0.001396019,0.0001493087,0.0003341724],"domain_scores_gemma":[0.9981744,0.0003923082,0.0005807304,0.0004987193,0.0002285358,0.0001253388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001630392,0.00007444021,0.9288957,0.000007816401,0.002151777,0.000001208031,0.001222067,0.0001053826,0.01060834,0.0000488667,0.01934188,0.03591212],"study_design_scores_gemma":[0.003132966,0.0005186806,0.9732367,0.0000413211,0.0005989663,0.000009445755,0.001138841,0.0002901782,0.003279075,0.004407448,0.01298562,0.0003607376],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660875,0.020836,0.001985904,0.006572541,0.000983757,0.001722888,0.001738277,0.00002494897,0.00004814432],"genre_scores_gemma":[0.9892514,0.005415473,0.00159778,0.001029358,0.0008490529,0.0005680089,0.001111439,0.00002931642,0.0001481252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04434101,"threshold_uncertainty_score":0.9999731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642737889447706,"score_gpt":0.329091000216641,"score_spread":0.302663621322164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}