{"id":"W2040063892","doi":"10.1158/1055-9965.epi-08-0546","title":"Reproductive and Hormonal Factors, and Ovarian Cancer Risk for <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers: Results from the International <i>BRCA1/2</i> Carrier Cohort Study","year":2009,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Cancer Research UK","keywords":"Ovarian cancer; Hazard ratio; Medicine; Oncology; Gynecology; BRCA mutation; Population; Confidence interval; Cancer; Obstetrics; Proportional hazards model; Cohort; Internal medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118807,0.0003292042,0.0003583319,0.0008646478,0.0002541419,0.0004196169,0.0003340559,0.0003051167,0.001226783],"category_scores_gemma":[0.002264231,0.0002208084,0.0009428634,0.0009102881,0.0001937363,0.0002456459,0.000329818,0.0003882363,0.0001216599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296853,"about_ca_system_score_gemma":0.0003187547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009160776,"about_ca_topic_score_gemma":0.01082525,"domain_scores_codex":[0.9997185,0.00006523456,0.00002606673,0.00008958529,0.00005577786,0.00004480599],"domain_scores_gemma":[0.9989579,0.0002546608,0.0004081942,0.0001287633,0.00008390626,0.000166474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002295699,0.00001774209,0.9984419,0.00001044172,0.0001214679,0.00003674386,0.00003154764,0.0000259707,0.0001254697,0.000007502723,0.0000621673,0.0008896158],"study_design_scores_gemma":[0.00001485645,0.00006168242,0.9993463,0.00000601442,0.0001386661,0.0001358366,0.00003599269,0.00005853757,0.00004151684,0.00001206867,0.0001461712,0.000002413341],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979247,0.0008935852,0.00007455443,0.0000301549,0.000004760336,0.0000116527,0.0008413483,0.000002257502,0.000217035],"genre_scores_gemma":[0.9981426,0.0003755844,0.0001524976,0.00002023317,0.000009152112,0.00001560254,0.001106195,0.000002915143,0.0001753018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009160776,"threshold_uncertainty_score":0.01821494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642737889447706,"score_gpt":0.329091000216641,"score_spread":0.302663621322164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}