{"id":"W2040096647","doi":"10.4161/cc.29215","title":"Inhibition of histone deacetylases enhances DNA damage repair in SCNT embryos","year":2014,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Ste. Anne's Hospital","funders":"Ciência sem Fronteiras","keywords":"Somatic cell nuclear transfer; Biology; Reprogramming; Blastocyst; DNA damage; Histone; DNA repair; Embryo; Cell biology; Somatic cell; Molecular biology; Genetics; Embryogenesis; DNA; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003019296,0.0004123303,0.0005915397,0.0002767826,0.000126518,0.0003033752,0.0003514837,0.0003380589,0.00166807],"category_scores_gemma":[0.0002115624,0.0002448367,0.0004634979,0.0001689831,0.0002397108,0.0001932909,0.0002304713,0.0009376148,0.0003794292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003658738,"about_ca_system_score_gemma":0.000300228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009250878,"about_ca_topic_score_gemma":0.0021588,"domain_scores_codex":[0.9997436,0.00003074589,0.00005043766,0.00007273684,0.00006832198,0.0000341529],"domain_scores_gemma":[0.9998043,0.00004563367,0.00005879076,0.00002001421,0.00001960353,0.000051756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008967099,0.00002095039,0.00009330419,0.0000514108,0.000008688124,0.00003060528,0.00001095061,0.00004782813,0.9985653,0.00003959118,0.00002954377,0.001012241],"study_design_scores_gemma":[0.000044095,0.000595081,0.003881295,0.00001263109,0.00002753559,0.0001201555,0.00001899567,0.0008353808,0.9919637,0.00003249272,0.002463446,0.000005147341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752198,0.007423971,0.01021861,0.0003746343,0.0003579255,0.0002216162,0.001512298,0.0004574266,0.004213658],"genre_scores_gemma":[0.9772508,0.004336403,0.009662978,0.0003073544,0.00004606714,0.0002270144,0.001926092,0.0001290005,0.006114536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166807,"threshold_uncertainty_score":0.005580246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007701091770562138,"score_gpt":0.2691938697874925,"score_spread":0.2614927780169303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}