{"id":"W2040111212","doi":"10.1038/nprot.2015.021","title":"Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells","year":2015,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Cystic fibrosis; Cell biology; Progenitor cell; Stem cell; Regeneration (biology); Biology; Cellular differentiation; Cystic fibrosis transmembrane conductance regulator; Directed differentiation; Transmembrane protein; Immunology; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001514472,0.0003927433,0.0003415201,0.0003717163,0.0002689722,0.0006813916,0.0004643199,0.0007799906,0.002324823],"category_scores_gemma":[0.0007934837,0.0002976907,0.0004074869,0.0002928913,0.0003039942,0.0003588888,0.0005132802,0.001129395,0.001067061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001853491,"about_ca_system_score_gemma":0.0003388379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001978266,"about_ca_topic_score_gemma":0.0004017107,"domain_scores_codex":[0.9993141,0.0001197339,0.0001406951,0.00009776125,0.0002425816,0.00008517038],"domain_scores_gemma":[0.9996434,0.0001020677,0.00005572359,0.00006862517,0.00008823487,0.00004189499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005669224,0.00002032979,0.000157609,0.00007952896,0.000009115966,0.0001045866,0.00006009725,0.000274079,0.9931675,0.001219985,0.0004698879,0.004380545],"study_design_scores_gemma":[0.00004095516,0.0001384802,0.0009346236,0.00002540775,0.00002888756,0.0003847268,0.00004882814,0.002252955,0.9817442,0.0003367998,0.01405151,0.0000124541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.715157,0.004499848,0.2504219,0.001380661,0.0009496249,0.001912281,0.01088684,0.001405519,0.01338632],"genre_scores_gemma":[0.9241551,0.002114369,0.05636179,0.0003830116,0.00006645237,0.000709731,0.006861979,0.0001934145,0.009154092],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002324823,"threshold_uncertainty_score":0.008009374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1160358285085847,"score_gpt":0.3922048470502537,"score_spread":0.276169018541669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}