{"id":"W2040121180","doi":"10.1038/ncomms7753","title":"Transcriptional refractoriness is dependent on core promoter architecture","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft","keywords":"Promoter; RNA polymerase II; Transcription (linguistics); Biology; Transcriptional regulation; RNA polymerase; Gene; Transcription factor; Population; Genetics; RNA; Gene expression; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001643033,0.0001378344,0.0001098512,0.00005569695,0.0001160634,0.00001929685,0.0007662132,0.0003313538,0.00001788974],"category_scores_gemma":[0.00005441361,0.0001227998,0.0001070929,0.0001549388,0.00007519446,0.000002652662,0.0001567154,0.0004967028,0.0000218007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003206358,"about_ca_system_score_gemma":0.0000925573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000453812,"about_ca_topic_score_gemma":0.0001988397,"domain_scores_codex":[0.9991441,0.00008753369,0.0001470314,0.0002491532,0.0002257432,0.0001464519],"domain_scores_gemma":[0.9978197,0.00001375535,0.00006271991,0.001774882,0.0002145494,0.0001144138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000749498,0.00225613,0.04155027,0.00004954791,0.001686556,0.00001014062,0.002096044,0.005356628,0.6537074,0.01764385,0.2486683,0.0262257],"study_design_scores_gemma":[0.0005946856,0.0001553645,0.008449526,0.000015136,0.00007689073,0.00002493836,0.00006304116,0.0002273677,0.01638868,0.000827666,0.9728835,0.0002932345],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511906,0.01945478,0.001577634,0.01598136,0.0005474506,0.0005522678,0.0001572558,0.00007545677,0.0104632],"genre_scores_gemma":[0.9941007,0.0001558807,0.002564955,0.001141478,0.000224836,0.00003342785,0.0005742904,0.00002077696,0.001183594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7242152,"threshold_uncertainty_score":0.5007632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03632421604675666,"score_gpt":0.3077371550110403,"score_spread":0.2714129389642836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}