{"id":"W2040121180","doi":"10.1038/ncomms7753","title":"Transcriptional refractoriness is dependent on core promoter architecture","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft","keywords":"Promoter; RNA polymerase II; Transcription (linguistics); Biology; Transcriptional regulation; RNA polymerase; Gene; Transcription factor; Population; Genetics; RNA; Gene expression; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268417,0.0001455415,0.0001833482,0.0002439852,0.00009761472,0.0003742168,0.0001883957,0.0001093605,0.0004528299],"category_scores_gemma":[0.0003790558,0.0001470391,0.0001574696,0.0001687842,0.0001864324,0.0002044061,0.0002582766,0.0002672218,0.0001512824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695203,"about_ca_system_score_gemma":0.000136596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006601891,"about_ca_topic_score_gemma":0.0009374567,"domain_scores_codex":[0.9998788,0.00001098893,0.000007777217,0.00004837163,0.00003397454,0.00002018413],"domain_scores_gemma":[0.9996727,0.00008123599,0.00009910212,0.00006177663,0.0000420316,0.00004316078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004835603,0.000004644931,0.002123839,0.00001543279,0.000003606862,0.00002646563,0.00001867792,0.0001822059,0.9956642,0.00008183457,0.000009143625,0.00182174],"study_design_scores_gemma":[0.000009956264,0.000178276,0.09586718,0.00001062387,0.00003578444,0.0005526281,0.00008837665,0.00969579,0.8913839,0.000552608,0.001604814,0.00001996593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928303,0.0003787847,0.006031447,0.0000256447,0.000004393537,0.000008097059,0.0001481241,0.00008722502,0.0004860537],"genre_scores_gemma":[0.9979407,0.0002225451,0.001266996,0.00001215101,0.000002912917,0.000009983389,0.0002773897,0.00001765806,0.0002496887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006601891,"threshold_uncertainty_score":0.001955509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03632421604675666,"score_gpt":0.3077371550110403,"score_spread":0.2714129389642836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}