{"id":"W2040133943","doi":"10.3389/fphar.2012.00165","title":"Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking","year":2012,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal; McGill University; Cystic Fibrosis Canada","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Yale University; Cystic Fibrosis Canada; McGill University; McGill University Health Centre; Rosalind Franklin University of Medicine and Science; Université de Strasbourg; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Génome Québec; Cystic Fibrosis Foundation Therapeutics; Case Western Reserve University; Erasmus Universitair Medisch Centrum Rotterdam; Cystic Fibrosis Foundation","keywords":"Poly ADP ribose polymerase; Polymerase; Chemistry; Cell biology; Pharmacology; Molecular biology; Medicine; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002303191,0.000421761,0.0005262558,0.0002995704,0.0001381908,0.0005215026,0.0002902712,0.0004995991,0.001865298],"category_scores_gemma":[0.0002283544,0.0002292972,0.0003886377,0.0001898008,0.0002311366,0.0002004813,0.0002077212,0.001121573,0.000747595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404477,"about_ca_system_score_gemma":0.0002554703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005887092,"about_ca_topic_score_gemma":0.0005910235,"domain_scores_codex":[0.9996858,0.00003413955,0.00005661717,0.00007942576,0.00007377478,0.00007030783],"domain_scores_gemma":[0.9997266,0.00005303464,0.00007989699,0.00004881514,0.00003026276,0.00006140684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001385136,0.00005695368,0.0001030468,0.0000410301,0.000005385227,0.00003195732,0.00001066435,0.00007138048,0.997539,0.00004692174,0.00007709,0.001877923],"study_design_scores_gemma":[0.00003045064,0.0009156786,0.002798251,0.0000141747,0.00001604826,0.0003033576,0.00003436966,0.0008295448,0.9925068,0.00005223667,0.00249191,0.000007099219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887981,0.002450772,0.00496232,0.00023994,0.0001393186,0.00007903339,0.001237285,0.0005033939,0.00158991],"genre_scores_gemma":[0.9886194,0.002024388,0.004083174,0.0001704201,0.00002446934,0.00008170282,0.001614757,0.00008575145,0.003295922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865298,"threshold_uncertainty_score":0.00624007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218370715605522,"score_gpt":0.2842715851431492,"score_spread":0.272087877987094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}