{"id":"W2040138014","doi":"10.1371/journal.pone.0070047","title":"Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph's Hospital; McMaster University","funders":"Prostate Cancer Canada; McMaster University; Movember Foundation","keywords":"PTEN; Prostate cancer; Microvesicles; Cancer research; Tumor suppressor gene; Cancer; Suppressor; Downregulation and upregulation; Biology; Medicine; microRNA; Internal medicine; Apoptosis; Gene; Carcinogenesis; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004244917,0.0000945062,0.0001106496,0.000008790683,0.00005315441,0.0000146926,0.0001837692,0.00005122439,0.00008051553],"category_scores_gemma":[0.0003241092,0.00007277539,0.00008140499,0.00004350556,0.0000893828,0.000008131057,0.00008917161,0.00003772053,0.00000605384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009480857,"about_ca_system_score_gemma":0.00005196214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005744262,"about_ca_topic_score_gemma":0.00001210792,"domain_scores_codex":[0.9992737,0.00003608493,0.0001706815,0.0002024608,0.0001513019,0.000165818],"domain_scores_gemma":[0.9992967,0.00002827972,0.00011769,0.0003574392,0.0001633254,0.00003657523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005057167,0.0003671184,0.002051972,0.000149094,0.0001100316,3.033995e-7,0.00006064112,0.0000937584,0.9955838,0.00002894609,0.001319358,0.0001843826],"study_design_scores_gemma":[0.0005313819,0.00007672589,0.01976087,0.00008897062,0.0001392906,6.728493e-7,0.00002591064,0.0006210643,0.9771964,0.001254789,0.0001982405,0.0001057023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996597,0.001173933,0.0002280913,0.0005758779,0.00005449881,0.001159872,0.0001258011,0.000008287324,0.00007664257],"genre_scores_gemma":[0.9964406,0.0000737114,0.001443248,0.0001531306,0.0001763556,0.0006104381,0.00006732839,0.00002469263,0.0010105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01838744,"threshold_uncertainty_score":0.2967694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467432128763993,"score_gpt":0.2288204705088586,"score_spread":0.2141461492212187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}