{"id":"W2040138444","doi":"10.1073/pnas.212518799","title":"Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; York University; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"SH2 domain; Adapter molecule crk; Proto-oncogene tyrosine-protein kinase Src; Phosphopeptide; SH3 domain; GRB2; HAMP domain; B3 domain; EGF-like domain; Chemistry; Cell biology; Biology; Binding domain; Binding site; Biochemistry; Phosphorylation; Signal transducing adaptor protein; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604831,0.0003906404,0.0003865521,0.0002026742,0.000648035,0.0007469819,0.0007488061,0.0004399893,0.00156512],"category_scores_gemma":[0.000327949,0.000215849,0.0002598523,0.0001951532,0.0005044725,0.0003184134,0.0002473503,0.0007570501,0.0003080061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002199518,"about_ca_system_score_gemma":0.0005927701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00479296,"about_ca_topic_score_gemma":0.00393718,"domain_scores_codex":[0.9998369,0.00001522543,0.000005851357,0.00005723221,0.00004568929,0.00003904457],"domain_scores_gemma":[0.9998677,0.00002345417,0.00003125677,0.000008304238,0.00001382834,0.00005546847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001029363,0.0003696805,0.00217299,0.000143189,0.00007951613,0.001163536,0.0001892132,0.00608241,0.9788715,0.004539273,0.001107141,0.004252279],"study_design_scores_gemma":[0.001040156,0.001281901,0.08037552,0.00009792381,0.0001853658,0.003455395,0.0005090971,0.162139,0.7246928,0.004715588,0.02129054,0.0002167539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965712,0.0005560622,0.001104566,0.0001995754,0.00002596742,0.00001577555,0.000156536,0.0001080661,0.001262303],"genre_scores_gemma":[0.996365,0.0001937695,0.0012694,0.0001330025,0.00001148099,0.00002056107,0.0007025892,0.00002384362,0.001280273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00479296,"threshold_uncertainty_score":0.01595867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0278432367346007,"score_gpt":0.2579997589599789,"score_spread":0.2301565222253782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}