{"id":"W2040138444","doi":"10.1073/pnas.212518799","title":"Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; York University; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"SH2 domain; Adapter molecule crk; Proto-oncogene tyrosine-protein kinase Src; Phosphopeptide; SH3 domain; GRB2; HAMP domain; B3 domain; EGF-like domain; Chemistry; Cell biology; Biology; Binding domain; Binding site; Biochemistry; Phosphorylation; Signal transducing adaptor protein; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000738239,0.0001071382,0.0001283734,0.00004523615,0.0003544965,0.00002612423,0.0006032987,0.00009203015,0.00002892018],"category_scores_gemma":[0.0002259521,0.00005561713,0.00007571992,0.0003069943,0.001601868,0.00002296426,0.0002118786,0.000115943,1.566392e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001009438,"about_ca_system_score_gemma":0.00002081905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005360187,"about_ca_topic_score_gemma":4.04858e-7,"domain_scores_codex":[0.9987218,0.00001895818,0.0002860586,0.0002201844,0.0006174899,0.0001355397],"domain_scores_gemma":[0.9992467,0.00004435653,0.0004218032,0.00002585318,0.0002328427,0.00002846668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001472904,0.00001150402,0.0006922692,0.000031829,0.00002066916,4.242734e-9,0.0003167265,0.00006307949,0.982965,0.01486943,0.0008369943,0.0001777467],"study_design_scores_gemma":[0.0002563135,0.00004447093,0.02856174,0.00006956459,0.00001226837,0.00001492272,0.0006143054,0.0005315216,0.9304858,0.03804016,0.001276562,0.00009235091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937174,0.002083767,0.00000545139,0.003094127,0.00001005382,0.0002363363,0.00001708032,0.000003534383,0.0008323019],"genre_scores_gemma":[0.9976025,0.00008904788,0.001535476,0.0006297545,0.00008059989,0.000005660693,4.081927e-7,0.000004910206,0.00005160452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0524792,"threshold_uncertainty_score":0.5902149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0278432367346007,"score_gpt":0.2579997589599789,"score_spread":0.2301565222253782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}