{"id":"W2040146122","doi":"10.1182/blood-2009-07-231191","title":"The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute on Aging","keywords":"Leukemia; Myeloid leukemia; Ubiquitin; Cancer research; Clonogenic assay; Programmed cell death; Cell culture; Haematopoiesis; Cell growth; Biology; Chemistry; Cell; Apoptosis; Immunology; Cell biology; Biochemistry; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713946,0.000299863,0.0002842303,0.0002502552,0.0001068897,0.0002426112,0.0001822863,0.000275905,0.0006582214],"category_scores_gemma":[0.00005266177,0.00007919851,0.0002007705,0.0002550835,0.0001450657,0.0001813026,0.0002075142,0.0006314372,0.0001806002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700759,"about_ca_system_score_gemma":0.0002088757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002661724,"about_ca_topic_score_gemma":0.0007538871,"domain_scores_codex":[0.9999397,0.00001006738,0.000004894132,0.00001146462,0.0000186696,0.00001515008],"domain_scores_gemma":[0.9999756,0.000003561523,0.000009474688,0.000002719838,0.000003976002,0.000004781049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000520062,0.0002451932,0.0008083127,0.0003702547,0.00003091937,0.0002626871,0.0000248707,0.0005172885,0.9460572,0.0006664991,0.0005796932,0.04991699],"study_design_scores_gemma":[0.0002622973,0.004156664,0.009745109,0.00005121541,0.0001100809,0.002566368,0.00003691202,0.001872432,0.9299882,0.0004154836,0.05077372,0.00002152059],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7924002,0.184577,0.01413088,0.001734086,0.0002062768,0.0001632257,0.000561595,0.0003479983,0.005878703],"genre_scores_gemma":[0.9368307,0.05239487,0.005669036,0.000322516,0.00005747806,0.00005053378,0.0005624149,0.00001647497,0.00409597],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0006582214,"threshold_uncertainty_score":0.002201974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376707305500251,"score_gpt":0.2500680950477745,"score_spread":0.236301021992772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}