{"id":"W2040149023","doi":"10.1016/s0960-894x(01)00746-6","title":"Studies toward the discovery of the next generation of antidepressants. Part 2: Incorporating a 5-HT1A antagonist component into a class of serotonin reuptake inhibitors","year":2002,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Reuptake inhibitor; Serotonin; Pharmacology; Antagonist; Serotonin Uptake Inhibitors; Serotonin reuptake inhibitor; Fluoxetine; Biochemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023912,0.0002799293,0.0004567189,0.00003556678,0.000160718,0.00003012669,0.0007728545,0.00007587803,0.00004240703],"category_scores_gemma":[0.0004136133,0.0001756938,0.0001607229,0.0004919146,0.001724952,0.0002308295,0.0001956015,0.0003631473,0.000002058159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008026846,"about_ca_system_score_gemma":0.00004965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004668046,"about_ca_topic_score_gemma":0.000002949568,"domain_scores_codex":[0.9972572,0.0001926735,0.0009286949,0.0004596918,0.0008992088,0.0002625365],"domain_scores_gemma":[0.9981323,0.0001832689,0.0008846667,0.0006613127,0.00008201328,0.00005643614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002201343,0.0001043202,0.006585745,0.0002900877,0.00002102262,0.00001215662,0.001952308,0.00001139602,0.9899516,0.000007507754,0.000800864,0.000240957],"study_design_scores_gemma":[0.0004319062,0.00004789717,0.0009748736,0.0003589395,0.00007785854,0.00004225077,0.000788778,0.00008598089,0.9969285,0.00000544538,0.000107084,0.000150466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905959,0.0003003167,0.00001809479,0.008127807,0.0004333822,0.0004487822,0.00002949068,0.00002217842,0.00002404547],"genre_scores_gemma":[0.9985136,0.0001052754,0.00004284702,0.001041828,0.0002167781,0.0000310464,0.000002545518,0.00002735836,0.00001868175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007917737,"threshold_uncertainty_score":0.7164585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1279318855790308,"score_gpt":0.2887453929941638,"score_spread":0.160813507415133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}