{"id":"W2040175790","doi":"10.1016/j.jconrel.2014.11.031","title":"Irinophore C™, a lipid nanoparticulate formulation of irinotecan, improves vascular function, increases the delivery of sequentially administered 5-FU in HT-29 tumors, and controls tumor growth in patient derived xenografts of colon cancer","year":2014,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Centre for Drug Research and Development; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Irinotecan; Apoptosis; Medicine; TUNEL assay; CD31; Colorectal cancer; Cancer research; Pharmacology; Drug delivery; Survivin; Chemistry; Pathology; Angiogenesis; Cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392794,0.0002978983,0.0002195517,0.000190672,0.0001069269,0.0001906524,0.0001314696,0.0002105174,0.0007022333],"category_scores_gemma":[0.000114711,0.0001347295,0.0001398546,0.00009411394,0.0001593269,0.0002953494,0.0001159595,0.0005303925,0.000194933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002955846,"about_ca_system_score_gemma":0.0002556237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005119914,"about_ca_topic_score_gemma":0.001088479,"domain_scores_codex":[0.9999295,0.00001241819,0.000003306484,0.00001623017,0.00002544637,0.00001302789],"domain_scores_gemma":[0.9999477,0.00000827669,0.00002057593,0.000003524662,0.000005194429,0.00001463156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004044979,0.0001138798,0.0001108553,0.00005492704,0.000009857187,0.00005541267,0.0000159781,0.0001178075,0.9888464,0.00009153072,0.00017999,0.009998958],"study_design_scores_gemma":[0.0001313592,0.002410796,0.002228101,0.000005911394,0.00004858068,0.0005372836,0.00001050603,0.0007727011,0.990073,0.00002259442,0.003750322,0.000008845156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894275,0.003173981,0.004487215,0.0002051623,0.00005549702,0.00006073095,0.0001359185,0.0001862833,0.002267743],"genre_scores_gemma":[0.987301,0.002256488,0.005824342,0.0001003595,0.00003131165,0.00002894413,0.0003257442,0.00003149145,0.004100354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007022333,"threshold_uncertainty_score":0.002349198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005508199773843043,"score_gpt":0.2317070660415858,"score_spread":0.2261988662677427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}