{"id":"W2040175790","doi":"10.1016/j.jconrel.2014.11.031","title":"Irinophore C™, a lipid nanoparticulate formulation of irinotecan, improves vascular function, increases the delivery of sequentially administered 5-FU in HT-29 tumors, and controls tumor growth in patient derived xenografts of colon cancer","year":2014,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Centre for Drug Research and Development; BC Cancer Agency","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Irinotecan; Apoptosis; Medicine; TUNEL assay; CD31; Colorectal cancer; Cancer research; Pharmacology; Drug delivery; Survivin; Chemistry; Pathology; Angiogenesis; Cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004084269,0.0001435276,0.0005760301,0.0001513456,0.00002859009,0.00001089739,0.000105735,0.0000632087,0.00000571763],"category_scores_gemma":[0.000355114,0.00009673301,0.0002050557,0.0001180143,0.00009982286,0.0000197834,0.00004759401,0.0001066244,7.126325e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003998848,"about_ca_system_score_gemma":0.0003325243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552026,"about_ca_topic_score_gemma":0.001643656,"domain_scores_codex":[0.9982725,0.0002918023,0.0008298716,0.0001451885,0.0002716433,0.0001889634],"domain_scores_gemma":[0.9983083,0.00009174603,0.0008445923,0.000155376,0.0005008717,0.00009912665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02263357,0.0004779692,0.01110351,0.0001190541,0.0004272299,0.00003179173,0.00006918464,0.0004823335,0.9608043,0.00002124361,0.00001871237,0.003811056],"study_design_scores_gemma":[0.06817776,0.009741866,0.1432346,0.0006113038,0.000526929,0.00007658191,0.0001466259,0.00276143,0.7739991,0.0002005207,0.0002657017,0.0002576375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941214,0.005056328,0.00007167182,0.00006902251,0.00004601048,0.0005988935,0.0000256341,0.000001004807,0.000009975434],"genre_scores_gemma":[0.9988138,0.0009486135,0.00004789279,0.00006175997,0.00005810815,0.00004712181,0.000008250502,0.00001119488,0.000003248265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1868053,"threshold_uncertainty_score":0.3944658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005508199773843043,"score_gpt":0.2317070660415858,"score_spread":0.2261988662677427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}