{"id":"W2040177711","doi":"10.1007/s10620-014-3167-6","title":"Caspase 3 Inactivation Protects Against Hepatic Cell Death and Ameliorates Fibrogenesis in a Diet-Induced NASH Model","year":2014,"lang":"en","type":"article","venue":"Digestive Diseases and Sciences","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; University of Toronto","keywords":"Hepatology; Transplant surgery; Apoptosis; Programmed cell death; Hepatic stellate cell; Caspase 3; Medicine; Internal medicine; Chemistry; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008952628,0.0001528388,0.0002116348,0.0001219837,0.0002279081,0.00009142137,0.00004106339,0.00003076806,0.000002182498],"category_scores_gemma":[0.0001209755,0.0001087408,0.0000378994,0.0002209717,0.000163781,0.000195981,0.00003844757,0.000038021,0.000001272855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003993317,"about_ca_system_score_gemma":0.0001391425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002280937,"about_ca_topic_score_gemma":0.000008095413,"domain_scores_codex":[0.9990394,0.00004742154,0.0001273937,0.0003781602,0.0002048545,0.0002027982],"domain_scores_gemma":[0.9994286,0.00012282,0.00005939334,0.00009265677,0.00005542103,0.0002411602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001153567,0.0004196704,0.9942555,0.00009989178,0.0000120998,0.00001951894,0.0002506228,0.0001890801,0.001264532,0.0002937183,0.000003802741,0.003076156],"study_design_scores_gemma":[0.0008142154,0.0006791582,0.9337378,0.0001784021,0.00007200777,9.11576e-7,0.0003066214,0.06055883,0.002961223,0.0005574317,0.000001807483,0.0001316301],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980326,0.0008615865,0.00002797457,0.0002328669,0.00001351585,0.0005328493,0.00002690226,0.00002053263,0.0002512024],"genre_scores_gemma":[0.9991368,0.0002404831,0.0002099806,0.0002159931,0.00001870692,0.0001481382,0.00001468713,0.000007023715,0.000008186206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06051779,"threshold_uncertainty_score":0.4434322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02537380588381777,"score_gpt":0.2703470475280654,"score_spread":0.2449732416442477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}