{"id":"W2040206050","doi":"10.1021/tx400224j","title":"Effect of Aminoglutethimide on Neutrophils in Rats: Implications for Idiosyncratic Drug-Induced Blood Dyscrasias","year":2013,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Bone marrow; Pharmacology; Neutrophilia; Myeloid; Medicine; Dyscrasia; Monocytosis; In vivo; Drug; Immunology; Granulopoiesis; Granulocyte; Internal medicine; Haematopoiesis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003198878,0.0007280181,0.0004892502,0.0005327092,0.0001790256,0.0002037189,0.0002754193,0.0006400928,0.001364339],"category_scores_gemma":[0.0003189131,0.0001947272,0.000407577,0.0001825077,0.0004533399,0.0002868513,0.0002112306,0.0007346079,0.0003111363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003186107,"about_ca_system_score_gemma":0.00030258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012537,"about_ca_topic_score_gemma":0.001684233,"domain_scores_codex":[0.9997699,0.0000788579,0.00001642481,0.0000406734,0.00004034014,0.0000539362],"domain_scores_gemma":[0.9996324,0.0000710242,0.0001158472,0.00004889011,0.00003329345,0.00009864853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00452057,0.0005387072,0.001115027,0.00009729411,0.00001263477,0.0003794317,0.00005424449,0.0001268028,0.9876721,0.0001110004,0.00007308699,0.005299112],"study_design_scores_gemma":[0.0001846171,0.01128483,0.01103253,0.00001397779,0.00004736785,0.0005122988,0.00009197581,0.0009015251,0.9743997,0.00008659944,0.001428279,0.00001633175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943742,0.002520283,0.0015748,0.0001599911,0.00005254464,0.00007560399,0.0002171473,0.00009371143,0.0009317825],"genre_scores_gemma":[0.9944592,0.001608951,0.001784326,0.00007985598,0.00002922424,0.00008874913,0.00021609,0.00001414988,0.001719396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001364339,"threshold_uncertainty_score":0.004564226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03998462253089348,"score_gpt":0.3857341018675134,"score_spread":0.3457494793366199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}