{"id":"W2040206938","doi":"10.1021/ol006740u","title":"Optimization of Palladium-Catalyzed Polyene Cyclizations:  Suppression of Competing Hydride Transfer from Tertiary Amines with Dabco and an Unexpected Hydride Transfer from 1,4-Dioxane","year":2001,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; DABCO; Hydride; Polyene; Catalysis; Palladium; Combinatorial chemistry; Organic chemistry; Medicinal chemistry; Hydrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003723169,0.0009493542,0.0004107375,0.0002679203,0.0002789829,0.0005453273,0.0004347173,0.0003517572,0.001224054],"category_scores_gemma":[0.000387642,0.0002974263,0.0002399814,0.0002445173,0.000313763,0.0003683666,0.0002271384,0.0005720955,0.0004355705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004178309,"about_ca_system_score_gemma":0.0003446611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005800502,"about_ca_topic_score_gemma":0.0019327,"domain_scores_codex":[0.9996794,0.00006106186,0.00004145047,0.00007929032,0.00005949221,0.00007922758],"domain_scores_gemma":[0.9997297,0.00008792595,0.00006988995,0.00002521678,0.00002818866,0.00005902771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002100501,0.0000826983,0.00007970208,0.0001051694,0.00001323338,0.0001040003,0.00003844266,0.0005050475,0.9966211,0.0001005305,0.00004245474,0.00209753],"study_design_scores_gemma":[0.00002102746,0.0002083203,0.000284699,0.000001951802,0.000009917356,0.00004637843,0.000009822665,0.0003545124,0.9985247,0.00001178517,0.0005202249,0.000006672023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896122,0.001130862,0.005318329,0.00008600637,0.00003684406,0.0001781337,0.0002982757,0.0001585081,0.00318083],"genre_scores_gemma":[0.9928799,0.001012834,0.004685374,0.00003005229,0.000008175703,0.00008751009,0.0002563623,0.00005483924,0.0009848943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224054,"threshold_uncertainty_score":0.004094839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008747841753097198,"score_gpt":0.2243203047176671,"score_spread":0.2155724629645699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}