{"id":"W2040210492","doi":"10.1074/jbc.m510032200","title":"The Smaller Isoforms of Ankyrin 3 Bind to the p85 Subunit of Phosphatidylinositol 3′-Kinase and Enhance Platelet-derived Growth Factor Receptor Down-regulation","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Cell biology; SH2 domain; GRB2; Proto-oncogene tyrosine-protein kinase Src; Ankyrin; Phosphorylation; Platelet-derived growth factor receptor; Signal transducing adaptor protein; Biology; Gene isoform; Receptor tyrosine kinase; Tyrosine phosphorylation; Biochemistry; Receptor; Growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002649073,0.0001193907,0.0003172878,0.00001859734,0.00007218948,0.000006483558,0.0001134535,0.0001687758,0.0004789383],"category_scores_gemma":[0.0003721109,0.00005222571,0.0001127471,0.0001094438,0.0001901957,0.00003739828,0.0000417661,0.0002631766,0.000004892092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002894904,"about_ca_system_score_gemma":0.00004460756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002812293,"about_ca_topic_score_gemma":0.000001339432,"domain_scores_codex":[0.9990433,0.00004475523,0.0005004707,0.0001147955,0.0001520817,0.0001445279],"domain_scores_gemma":[0.9987786,0.0002645058,0.0004396388,0.0001399256,0.0002663505,0.0001109427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001278539,0.00008793152,0.003111305,0.00003988986,0.00005012981,0.000002314617,0.0001300106,0.0000118054,0.9856063,0.000007159219,0.0004581517,0.00921646],"study_design_scores_gemma":[0.0006408946,0.0005516164,0.06618997,0.00006000731,0.00001569007,0.00006465385,0.0001676007,0.00002750396,0.9251007,0.00002676319,0.007092224,0.00006239829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966289,0.0006335535,0.00009797807,0.002273663,0.00009180793,0.0001196265,0.00001234175,0.000005184495,0.0001369571],"genre_scores_gemma":[0.9979156,0.0008053809,0.0004550476,0.0002313418,0.0003660205,0.000002455738,0.000007208085,0.000005044928,0.0002118959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06307866,"threshold_uncertainty_score":0.5244039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948105361818289,"score_gpt":0.255954352829615,"score_spread":0.2364732992114321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}