{"id":"W2040210492","doi":"10.1074/jbc.m510032200","title":"The Smaller Isoforms of Ankyrin 3 Bind to the p85 Subunit of Phosphatidylinositol 3′-Kinase and Enhance Platelet-derived Growth Factor Receptor Down-regulation","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Cell biology; SH2 domain; GRB2; Proto-oncogene tyrosine-protein kinase Src; Ankyrin; Phosphorylation; Platelet-derived growth factor receptor; Signal transducing adaptor protein; Biology; Gene isoform; Receptor tyrosine kinase; Tyrosine phosphorylation; Biochemistry; Receptor; Growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009772686,0.0002983695,0.0001938559,0.0001379977,0.0001041868,0.0001734723,0.0001429952,0.0001804651,0.001108636],"category_scores_gemma":[0.00008898966,0.0001075572,0.0002510049,0.0001158556,0.0001472627,0.0001518263,0.0001894914,0.0005427752,0.0003088594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183909,"about_ca_system_score_gemma":0.0001318961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003781652,"about_ca_topic_score_gemma":0.0005707826,"domain_scores_codex":[0.999887,0.00001524607,0.000008530397,0.00001712286,0.00003376879,0.00003833851],"domain_scores_gemma":[0.9999152,0.00001784255,0.00001967052,0.000008598964,0.000007323802,0.00003141036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004445699,0.00001291333,0.00003771947,0.0000116247,0.000002389812,0.00001635261,0.000003601337,0.00001344839,0.9995472,0.00002478771,0.00001665762,0.0002687784],"study_design_scores_gemma":[0.00001954139,0.000225942,0.005188766,0.000002905028,0.00001562174,0.0002748467,0.00001870048,0.0004567626,0.9917694,0.00003104026,0.001993468,0.000003058062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997353,0.0007808813,0.001102933,0.00004737513,0.00001694852,0.00001291495,0.00008588179,0.00003228138,0.0005677859],"genre_scores_gemma":[0.9965199,0.0004480827,0.001050172,0.00005411849,0.00000751018,0.00002102782,0.0003245069,0.00001201333,0.001562568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108636,"threshold_uncertainty_score":0.00370878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948105361818289,"score_gpt":0.255954352829615,"score_spread":0.2364732992114321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}