{"id":"W2040223255","doi":"10.1016/j.abb.2004.03.033","title":"Maximization of the rate of chloride conduction in the CFTR channel pore by ion–ion interactions","year":2004,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; Ion; Chloride channel; Chemistry; Ion channel; Conductance; Ion transporter; Permeation; Cystic fibrosis; Biophysics; Chloride; Thermal conduction; Membrane; Biochemistry; Thermodynamics; Biology; Physics; Organic chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009602389,0.0003883227,0.0005260088,0.0002027949,0.0004886987,0.001186057,0.0004121996,0.0007095436,0.001871591],"category_scores_gemma":[0.002958744,0.0003470544,0.0002614569,0.0001227591,0.0006265416,0.001205832,0.0007884188,0.0006030793,0.0005753143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004566681,"about_ca_system_score_gemma":0.0003256267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001664597,"about_ca_topic_score_gemma":0.0001791168,"domain_scores_codex":[0.9997055,0.0001097304,0.00001417505,0.00005562415,0.00005042732,0.00006451616],"domain_scores_gemma":[0.9987794,0.0007714696,0.0001517219,0.00007238323,0.00009232995,0.0001328582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001498167,0.0001584008,0.00226822,0.0002340741,0.0000431799,0.0004347285,0.0001652699,0.0708755,0.8681468,0.04214423,0.0007931311,0.01323824],"study_design_scores_gemma":[0.0002362493,0.0007697225,0.004909026,0.00003439038,0.00007328224,0.0009554698,0.0002650271,0.4175883,0.5344496,0.03766835,0.002915152,0.0001355177],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9387549,0.0008705737,0.04466126,0.0009311069,0.00007735407,0.00002614763,0.00005324119,0.0001517661,0.01447381],"genre_scores_gemma":[0.9962793,0.0002167518,0.002284659,0.00002874712,0.00002422159,0.00001860995,0.00001895152,0.0000408427,0.001087907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001871591,"threshold_uncertainty_score":0.006261051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010207140776493,"score_gpt":0.2610676101582299,"score_spread":0.250965538750465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}