{"id":"W2040234021","doi":"10.1074/jbc.m113.511808","title":"Phosphatidylinositol 4,5-Biphosphate (PIP2) Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-Cell ATP-sensitive Potassium Channels","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Sulfonylurea receptor; Potassium channel; Chemistry; Phosphatidylinositol; Protein subunit; Biophysics; Inward-rectifier potassium ion channel; Cell biology; HEK 293 cells; Biochemistry; Ion channel; Receptor; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052952,0.0002674361,0.0002333863,0.0001111462,0.0001522846,0.0003262631,0.0001571309,0.0002171461,0.000808657],"category_scores_gemma":[0.000098401,0.0001075715,0.0002305258,0.0001172612,0.0001617076,0.0002535786,0.0002153854,0.0004644264,0.0002105937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003169408,"about_ca_system_score_gemma":0.0001638202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005080795,"about_ca_topic_score_gemma":0.0008027044,"domain_scores_codex":[0.9998664,0.00001980733,0.00001630065,0.00002985662,0.00002870051,0.00003890322],"domain_scores_gemma":[0.999958,0.000005934526,0.00001280019,0.000003520358,0.000005439454,0.00001426092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009178874,0.00001047101,0.00009612372,0.00002373672,0.00000339278,0.00003103827,0.000008262239,0.00002736925,0.9993,0.00003279002,0.00001447377,0.0003604756],"study_design_scores_gemma":[0.00001495025,0.0001230083,0.007015776,0.00000391332,0.00001574893,0.00009490434,0.00003983635,0.0009671532,0.9906493,0.00004157292,0.001028649,0.000005173634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956759,0.001451776,0.001380573,0.0001045998,0.00002290807,0.00001939143,0.0003585549,0.00003957798,0.0009467785],"genre_scores_gemma":[0.9968914,0.0008341385,0.0009888452,0.00006557516,0.000005185689,0.00002956251,0.0002304252,0.00001207775,0.000942751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000808657,"threshold_uncertainty_score":0.002705216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277271755073825,"score_gpt":0.233167331061057,"score_spread":0.2203946135103188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}