{"id":"W2040261396","doi":"10.1038/srep03169","title":"Antioxidant Induces DNA Damage, Cell Death and Mutagenicity in Human Lung and Skin Normal Cells","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Tea Polyphenols and Effects","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"DNA damage; Apoptosis; Antioxidant; Programmed cell death; Lung cancer; Cancer research; DNA; Human skin; Cisplatin; Mechanism (biology); Cell; Biology; Chemistry; Cell biology; Molecular biology; Medicine; Biochemistry; Pathology; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007922539,0.0001536824,0.0002564465,0.0001937427,0.0002049087,0.000231834,0.00004699391,0.00008460286,0.0001318129],"category_scores_gemma":[0.00002945641,0.0001254298,0.00003826102,0.0002111773,0.0001951034,0.000245735,0.0001095809,0.0001677718,0.000009560634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002716154,"about_ca_system_score_gemma":0.00005468457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007457027,"about_ca_topic_score_gemma":0.00006219937,"domain_scores_codex":[0.9983667,0.0000397828,0.0003699014,0.0005919604,0.0002831139,0.0003485987],"domain_scores_gemma":[0.9991154,0.00002344396,0.0001492557,0.0004340365,0.00005532791,0.0002225018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000003460306,0.0001048372,0.08961386,0.0001395862,0.000006697173,0.000614917,0.0006878135,0.000001814464,0.9058279,0.00001277976,0.002167626,0.0008186764],"study_design_scores_gemma":[0.0003887547,0.00006104203,0.5557552,0.00007621251,0.00002532685,0.0002210214,0.0001300819,0.0002151545,0.4423252,0.0002580475,0.0003976842,0.000146323],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955602,0.0002600003,0.000005202019,0.0000570459,0.0009692453,0.000576312,9.856517e-7,0.00003407837,0.002536904],"genre_scores_gemma":[0.9962144,0.000006570924,0.0002437826,0.00004063775,0.00005173375,0.00001584445,0.000009986256,0.00001421459,0.003402808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4661413,"threshold_uncertainty_score":0.5114878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036863898773253,"score_gpt":0.2486168218497168,"score_spread":0.2382481828619843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}