{"id":"W2040267618","doi":"10.1172/jci41490","title":"Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network","funders":"University of Toronto; National Institute of Environmental Health Sciences; Canadian Breast Cancer Research Alliance; V Foundation for Cancer Research; Breast Cancer Research Foundation","keywords":"Cancer research; Biology; Progenitor cell; Breast cancer; Estrogen receptor; Mammary tumor; Tumor suppressor gene; Retinoblastoma; Progesterone receptor; Epithelial–mesenchymal transition; Pathology; Cancer; Stem cell; Carcinogenesis; Metastasis; Medicine; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002238442,0.0001922756,0.0005572798,0.0004151873,0.00005296023,0.00004568967,0.0001527697,0.0003368114,0.00004543477],"category_scores_gemma":[0.005957574,0.0001503149,0.0002166438,0.0003839823,0.000174998,0.0003470143,0.00003349153,0.002053803,0.00002271828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468315,"about_ca_system_score_gemma":0.001252317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004943672,"about_ca_topic_score_gemma":0.0001753353,"domain_scores_codex":[0.9968008,0.0002805908,0.001695966,0.0002714014,0.0006529244,0.0002982676],"domain_scores_gemma":[0.9972228,0.000496106,0.001135086,0.0002690532,0.0003370051,0.0005398921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005108855,0.001224682,0.2495743,0.0002456667,0.0002919837,0.001976934,0.0006504694,0.0002263182,0.7019088,0.0005522834,0.004425963,0.03381375],"study_design_scores_gemma":[0.01276941,0.007533206,0.3959537,0.001839429,0.0004703812,0.00123021,0.0003854499,0.002355975,0.5653087,0.002384531,0.009041381,0.0007275706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953036,0.00007392023,0.0001155672,0.001633538,0.002334669,0.0003494589,0.000003544765,0.0000290375,0.0001566853],"genre_scores_gemma":[0.990135,0.0001376595,0.006847318,0.001314953,0.001386494,0.00000907538,0.0000166328,0.00003881688,0.0001141104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1463795,"threshold_uncertainty_score":0.8922864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06079831594064462,"score_gpt":0.3635933413710733,"score_spread":0.3027950254304287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}