{"id":"W2040334851","doi":"10.1016/j.bmcl.2012.04.111","title":"The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Amine oxidase; Amine gas treating; Diamine oxidase; Amine oxidase (copper-containing); Semicarbazide; Selectivity; Enzyme; Stereochemistry; Diamine; Biochemistry; Structure–activity relationship; Enzyme inhibitor; Combinatorial chemistry; In vitro; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127553,0.000377138,0.0002622081,0.0001707537,0.0001290059,0.0002556427,0.0003892031,0.000306093,0.0006551573],"category_scores_gemma":[0.0001731247,0.0001503863,0.0002183216,0.00009538635,0.0001766956,0.0002039441,0.0001733563,0.000642866,0.0002711045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117034,"about_ca_system_score_gemma":0.0002485429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004685788,"about_ca_topic_score_gemma":0.001330602,"domain_scores_codex":[0.9999163,0.000009463924,0.000004260569,0.00001256452,0.00002359592,0.00003374642],"domain_scores_gemma":[0.9999384,0.00001098312,0.00001692931,0.0000054209,0.00001329917,0.00001490151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190733,0.0001370592,0.0002459773,0.00008020519,0.00001583182,0.0001349401,0.00003642036,0.0004415909,0.9702664,0.0007677294,0.0003464182,0.02733659],"study_design_scores_gemma":[0.000130974,0.001084501,0.001566457,0.000008299207,0.0000397917,0.000623184,0.00001309221,0.001836907,0.9831331,0.0001278395,0.0114235,0.00001221541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551213,0.01940988,0.01794568,0.0004738731,0.0001676093,0.0001378171,0.0002943675,0.0002590982,0.006190366],"genre_scores_gemma":[0.9830955,0.007624658,0.00506735,0.0001390406,0.00003991955,0.00006697168,0.0004694652,0.00001820084,0.003478921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006551573,"threshold_uncertainty_score":0.002261579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005147129034319806,"score_gpt":0.1896162598358286,"score_spread":0.1844691308015088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}