{"id":"W2040341646","doi":"10.1021/jp807327a","title":"Mechanism of Hydrogen Peroxide Production by Copper-Bound Amyloid Beta Peptide: A Theoretical Study","year":2009,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Memorial University of Newfoundland","funders":"","keywords":"Chemistry; Hydrogen peroxide; Protonation; Adduct; Superoxide; Copper; Catalytic cycle; Yield (engineering); Peptide; Peroxide; Photochemistry; Catalysis; Electron transfer; Stereochemistry; Organic chemistry; Enzyme; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003586732,0.0005788675,0.0009825793,0.000648418,0.001046406,0.0008239791,0.001737851,0.00131893,0.005200418],"category_scores_gemma":[0.0006914858,0.0004353408,0.0006508001,0.0004231524,0.001151277,0.001269502,0.0008452966,0.000550031,0.0003652773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009428302,"about_ca_system_score_gemma":0.0008638341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003892607,"about_ca_topic_score_gemma":0.001730539,"domain_scores_codex":[0.9998981,0.000029966,0.000003054614,0.000009738552,0.00002958972,0.00002953455],"domain_scores_gemma":[0.9997581,0.0001259087,0.00002418185,0.00002157518,0.00004365178,0.00002667347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001191274,0.0001753083,0.001384508,0.0003295484,0.00005094489,0.0006321023,0.0002556685,0.8022107,0.003573462,0.185347,0.00130594,0.004615664],"study_design_scores_gemma":[0.00006533117,0.00003428294,0.0002295741,0.00001153761,0.00001213067,0.00004355635,0.00005489114,0.978522,0.0004357247,0.02004236,0.0005402481,0.000008374775],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8232039,0.002104254,0.06982189,0.002257786,0.0001861541,0.0001806878,0.0003983554,0.0001884483,0.1016585],"genre_scores_gemma":[0.9828882,0.001135992,0.008836174,0.0002006917,0.00006821414,0.0001955051,0.0001214051,0.00005562662,0.006498269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005200418,"threshold_uncertainty_score":0.01739711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361279818282394,"score_gpt":0.2979838060348311,"score_spread":0.2843710078520071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}