{"id":"W2040371382","doi":"10.2967/jnumed.109.069716","title":"Methotrexate, Paclitaxel, and Doxorubicin Radiosensitize <i>HER2</i>-Amplified Human Breast Cancer Cells to the Auger Electron–Emitting Radiotherapeutic Agent <sup>111</sup>In-NLS-Trastuzumab","year":2010,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; McMaster University; University of Toronto","funders":"Cancer Research UK; Canadian Breast Cancer Research Alliance","keywords":"Trastuzumab; Doxorubicin; Chemistry; Methotrexate; Cancer research; Molecular biology; Cancer; Breast cancer; Chemotherapy; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122058,0.0002598936,0.000245142,0.00009536152,0.00009434604,0.0001988888,0.0001340084,0.0001995125,0.0009084858],"category_scores_gemma":[0.0001251726,0.0001100204,0.0001489352,0.0001010732,0.000143286,0.0001081361,0.000112025,0.0001797455,0.0002325877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000294375,"about_ca_system_score_gemma":0.0001066647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007098138,"about_ca_topic_score_gemma":0.001225157,"domain_scores_codex":[0.9998735,0.00003200774,0.00001157074,0.00002050111,0.00003391279,0.00002844702],"domain_scores_gemma":[0.9999334,0.0000175882,0.00002006895,0.00001204586,0.00000875876,0.000008259131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227092,0.00002109419,0.000366074,0.00002512629,0.000007984095,0.00003822404,0.00001666064,0.0001023459,0.9979031,0.00003410368,0.00003399593,0.00132859],"study_design_scores_gemma":[0.00001521527,0.000312484,0.003719129,0.00000252399,0.00001318218,0.0002104184,0.00001308028,0.0002989961,0.9943815,0.000006627403,0.001025455,0.000001403049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968441,0.001041313,0.0008280942,0.00003179772,0.000008884153,0.0000212017,0.00004676905,0.00002508316,0.001152809],"genre_scores_gemma":[0.996435,0.0007863216,0.0009608879,0.00002761954,0.000008327935,0.00002124318,0.0001219564,0.000009743047,0.001628945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009084858,"threshold_uncertainty_score":0.003039241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509579087297436,"score_gpt":0.3553990813217046,"score_spread":0.3303032904487302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}