{"id":"W2040404585","doi":"10.1371/journal.pone.0032887","title":"Targeted Disruption of Ephrin B1 in Cells of Myeloid Lineage Increases Osteoclast Differentiation and Bone Resorption in Mice","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of Waterloo; U.S. Department of Veterans Affairs","keywords":"Osteoclast; Bone resorption; RANKL; Cell biology; Chemistry; Conditional gene knockout; Resorption; Ephrin; Bone remodeling; Biology; Endocrinology; Signal transduction; Phenotype; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002196371,0.0005774169,0.0003941525,0.0008915764,0.0002777438,0.0004690331,0.0003025701,0.0006337098,0.00235684],"category_scores_gemma":[0.0001365149,0.0005313572,0.0004703922,0.0002319724,0.0004605133,0.0002418862,0.000364759,0.00129047,0.0008061731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004339395,"about_ca_system_score_gemma":0.0003345158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009318641,"about_ca_topic_score_gemma":0.001789169,"domain_scores_codex":[0.9996488,0.00004821204,0.00004253059,0.0000793071,0.0001064807,0.00007461632],"domain_scores_gemma":[0.9997311,0.00002325602,0.0001122763,0.00001531082,0.00001553351,0.0001025171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001617401,0.00003461709,0.0003091525,0.00003464093,0.00000692874,0.00009324106,0.000014715,0.00003560743,0.9982837,0.0001212516,0.00005695436,0.0008474852],"study_design_scores_gemma":[0.0001491599,0.0005957346,0.01831828,0.00004357222,0.00006177808,0.001447203,0.00007837945,0.000955946,0.9723814,0.0001894025,0.005763278,0.00001578796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865069,0.002802731,0.005926194,0.0004073684,0.00004962776,0.00008780265,0.001786801,0.000315187,0.002117406],"genre_scores_gemma":[0.9815643,0.0026416,0.005621068,0.00022579,0.00002125769,0.0001515843,0.001375602,0.0001142939,0.008284448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00235684,"threshold_uncertainty_score":0.007884383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04645199952396712,"score_gpt":0.2377982292599684,"score_spread":0.1913462297360012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}