{"id":"W2040404585","doi":"10.1371/journal.pone.0032887","title":"Targeted Disruption of Ephrin B1 in Cells of Myeloid Lineage Increases Osteoclast Differentiation and Bone Resorption in Mice","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of Waterloo; U.S. Department of Veterans Affairs","keywords":"Osteoclast; Bone resorption; RANKL; Cell biology; Chemistry; Conditional gene knockout; Resorption; Ephrin; Bone remodeling; Biology; Endocrinology; Signal transduction; Phenotype; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978079,0.00008757365,0.0002126451,0.0001878487,0.00001839476,0.000005322671,0.00005692528,0.00005123093,0.00002028387],"category_scores_gemma":[0.0002806804,0.0000888449,0.00002022148,0.0002742781,0.00004975822,0.0002795723,0.0000449353,0.0001091191,0.000004247925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002256003,"about_ca_system_score_gemma":0.00000857784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001383205,"about_ca_topic_score_gemma":0.00005736084,"domain_scores_codex":[0.998889,0.0001625694,0.0003599575,0.000170101,0.0002458089,0.0001725707],"domain_scores_gemma":[0.9994256,0.0002243165,0.0001965973,0.00008895952,0.00002203287,0.00004247535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001406983,0.001035056,0.06588812,0.0001236074,0.000001841797,0.000001169088,0.0002487109,0.000009088741,0.9323347,0.00004772515,7.805078e-7,0.0001685384],"study_design_scores_gemma":[0.0004052289,0.0000692175,0.2001705,0.0001865201,0.00001169592,5.484071e-7,0.00002692197,0.0006688511,0.7983791,0.00001868971,0.000001206315,0.00006149507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994627,0.0001805567,0.00003957826,0.0000216244,0.00002015477,0.0002099328,0.00001928437,0.00001124511,0.00003493631],"genre_scores_gemma":[0.9994335,0.0002697015,0.0001718548,0.00003629456,0.0000383987,0.00001092054,0.000007125701,0.00001008643,0.00002212247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1342824,"threshold_uncertainty_score":0.362299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04645199952396712,"score_gpt":0.2377982292599684,"score_spread":0.1913462297360012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}